Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway

<div>Effects and mechanisms of hypoxia pretreatment promote angiogenesis of huMSC-derived sEVs after myocardial infarction. Hypoxia pretreatment upregulates the expression level of miR-214 and increased miR-214 expression in the vesicles (MSC<sup>hyp</sup>-sEVs). MSC<sup>hyp</sup>-sEVs can be efficiently internalized by endothelial cells and activates hedgehog pathway resulting in modulation of angiogenesis.</div>

Stem Cells International

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Figure 7: Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway 

Figure 7 | Hypoxia-Elicited Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Myocardial Infarction by Promoting Angiogenesis through the miR-214/Sufu Pathway 