Therapeutic Efficiency of Nasal Mucosa-Derived Ectodermal Mesenchymal Stem Cells in Rats with Acute Hepatic Failure

Figure 4

H&E staining of GC and EMSC-GC scaffolds on the liver in vivo. Small insets depict an overview of the GC scaffolds and liver tissues. The border between the GC scaffolds and the liver parenchyma is represented by larger figures. Day 2: the borders of the GC matrices (the triangle) and the liver parenchyma (the square) were clear in the sections. Day 5: neovascularization was observed in the EMSC-GC groups (arrowhead). Day 7: the number of new blood vessels decreased, whereas the inflammatory cells markedly infiltrated the control group (arrowhead). Day 14: the neovascularized areas receded with limited inflammatory cell infiltration in the EMSC-GC group and a large amount of inflammatory cell infiltration in the control group. Month 1: in the EMSC-GC groups, some hepatocyte-like cells with large nuclei, abundant cytoplasm, and light color were observed at the edges of the scaffold (arrowhead). .