Stem Cells International

Stem/Progenitor Cells in Cardiopulmonary Health, Disease, and Treatment


Status
Published

1Justus Liebig University Giessen, Giessen, Germany

2Columbia University, New York, USA

3Universities of Giessen and Marburg Lung Center, Giessen, Germany

4Chinese University of Hong Kong, Sha Tin, Hong Kong

5Justus Liebig University, Giessen, Germany


Stem/Progenitor Cells in Cardiopulmonary Health, Disease, and Treatment

Description

Cardiopulmonary system comprises various organs, structures, and substances from both the heart and lung system. Since the cardiopulmonary system interacts intimately with every other system in the body, and our health is closely related to the functioning of the cardiopulmonary system, its health and maintenance was always in center of attention by scientists and clinicians. Despite the plentiful research in this area, cardiopulmonary diseases still remain widely prevalent and are known as a significant and devastating cause of morbidity and mortality in the globe. The most common cardiopulmonary diseases are hypertension, chronic obstructive pulmonary disease, coronary heart disease, and rheumatic heart fever. Generally, cardiopulmonary disorders have a poor prognosis and current treatments only offer a modest improvement in symptoms without repairing the damaged tissues in the heart or lung system. But recent progress in the field of stem cell science, regenerative medicine, and tissue engineering offered a new perspective in the treatment of cardiopulmonary disorders.

This great achievement provided tremendous potential to develop disease- and patient-specific induced pluripotent stem (iPS) cells as well as organoid cultures for understanding a detailed insight into the pathomechanisms of various cardiopulmonary disorders which is important in drug discovery and treatment of patients. Furthermore, this revolutionized progress in the stem cells field has opened a great opportunity for novel personalized regenerative therapeutic approaches of cardiopulmonary disorders. There is abundant and even growing number of evidence in stem/progenitor cell therapy of various cardiopulmonary disorders of which some generated controversy information. To summarize and incorporate these scattered data and develop a more comprehensive understanding on impact of stem/progenitor cells in cardiopulmonary health and treatment, the present special issue is initiated to cover research from diverse disciplines related to the cardiopulmonary health.

Goal of this special issue is to gather the necessary perspectives to direct future scientific efforts toward the clinical application of stem/progenitor cells in treatment of cardiopulmonary disorders. Therefore, we would like to invite investigators in the related fields to contribute their original insights as well as in depth review articles which will support our goal for more comprehensive understanding and identification of the impact of stem/progenitor cells in treatment of cardiopulmonary disorders as well as cardiopulmonary disease modelling using disease- and patient-specific generated iPS cells and heart as well as lung organoid culture approaches.

Potential topics include but are not limited to the following:

  • Characterization of tissue specific stem cells as well as progenitor cells in the cardiopulmonary system
  • Stem/progenitor cells in the health of cardiopulmonary system
  • Infection, stem/progenitor cells, and the cardiopulmonary system
  • Cardiopulmonary disease modeling (disease- as well as patient-specific iPS cells, organoid cultures)
  • Biomaterials in cardiopulmonary regenerative therapy
  • Epigenetics as well as microRNAs in regenerative therapy
  • Mitochondria, stem/progenitor cells, and the cardiopulmonary system
  • Physiology and pathophysiology of cardiopulmonary diseases (using specific disease model approaches such as patient-specific iPS cells or organoid culture)
  • Clinical applications of stem/progenitor cells in the treatment of various cardiopulmonary diseases

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 9861403
  • - Editorial

Stem/Progenitor Cells in Cardiopulmonary Health, Disease, and Treatment

Fatemeh Sharifpanah | Hossein A. Ghofrani | ... | Heinrich Sauer
  • Special Issue
  • - Volume 2018
  • - Article ID 9215792
  • - Research Article

The Milk Thistle (Silybum marianum) Compound Silibinin Inhibits Cardiomyogenesis of Embryonic Stem Cells by Interfering with Angiotensin II Signaling

Enas Hussein Ali | Fatemeh Sharifpanah | ... | Heinrich Sauer
  • Special Issue
  • - Volume 2018
  • - Article ID 3123961
  • - Review Article

Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration

Adegbenro Omotuyi John Fakoya | David Adeiza Otohinoyi | Joshua Yusuf
  • Special Issue
  • - Volume 2018
  • - Article ID 9591421
  • - Research Article

Correlation between Therapeutic Efficacy of CD34+ Cell Treatment and Directed In Vivo Angiogenesis in Patients with End-Stage Diffuse Coronary Artery Disease

Tien-Hung Huang | Cheuk-Kwan Sun | ... | Fan-Yen Lee
  • Special Issue
  • - Volume 2018
  • - Article ID 9652897
  • - Review Article

The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant

Judith Gronbach | Tayyab Shahzad | ... | Harald Ehrhardt
  • Special Issue
  • - Volume 2018
  • - Article ID 5832460
  • - Research Article

Mesenchymal Stromal Cells Cultured in Serum from Heart Failure Patients Are More Resistant to Simulated Chronic and Acute Stress

Timo Z. Nazari-Shafti | Zhiyi Xu | ... | Christof Stamm
  • Special Issue
  • - Volume 2018
  • - Article ID 3814747
  • - Research Article

A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming

Yang Zhou | Sahar Alimohamadi | ... | Li Qian
  • Special Issue
  • - Volume 2018
  • - Article ID 1435746
  • - Review Article

Direct Cardiac Reprogramming: Progress and Promise

James L. Engel | Reza Ardehali
  • Special Issue
  • - Volume 2018
  • - Article ID 8283648
  • - Review Article

Cardiac Progenitor Cells in Basic Biology and Regenerative Medicine

Nevin Witman | Makoto Sahara
  • Special Issue
  • - Volume 2017
  • - Article ID 7849851
  • - Review Article

Myocardial Regeneration via Progenitor Cell-Derived Exosomes

Janita A. Maring | Christien M. Beez | ... | Christof Stamm
Stem Cells International
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Acceptance rate44%
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CiteScore7.200
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