Stem Cells International

Environmental Stimulus on Stem Cell Behaviour


Status
Published

Lead Editor

1University of Regina, Regina, Canada

2University of Toronto, Toronto, Canada

3University of Chicago, Chicago, USA


Environmental Stimulus on Stem Cell Behaviour

Description

There is much interest in stem cell biology not only for their potentiality to repair lost or damaged tissue, but also for their proposed involvement in cancer biology. This is in addition to their unique ability to self-renew and to differentiate into multiple cell lineages. In the biological setting, these cells reside in environments that experience significantly lower O2 partial pressures than the external environment. In addition to the unique O2 environment are the special metabolic requirements of undifferentiated cells, which likely play a critical role in stem cell biology. This extracellular environment is known to change, not only in the research setting, but also during pathology. These alterations in O2 availability can cause changes in ROS production, activation of specific signalling pathways, and alterations in ion channel function, ultimately all of which can change the biological activity of stem cells.

The focus of this special issue will be to shed further light on this complex interplay between environmental stimuli such as O2 availability, metabolic function, and paracrine signalling pathways. We would like to invite you to submit or recommend original research papers and reviews to this issue.

Potential topics include but are not limited to the following:

  • Effects of changes of oxygen concentration on stem cell development
  • Role of environmental stimulus (signalling molecules) in regulation of stem cells: underlying molecular pathways
  • Mutual interaction of stem cells and their niche
  • Role of ion channels and cell physiology on stem cell development
  • The effect of redox state of the cell on stem cell development and function: effect of ROS/RNS, antioxidants
  • Mitochondrial function in signalling pathways involved in stem cell biology
  • Stem cells and diseases
  • Autophagy and stem cell development/differentiation
  • Effects of drugs and alcohol on stem cell biology and development

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 4910185
  • - Editorial

Environmental Stimulus on Stem Cell Behaviour

Eftekhar Eftekharpour | Josef Buttigieg
  • Special Issue
  • - Volume 2017
  • - Article ID 2362630
  • - Research Article

Molecular Genetic Analysis of Human Endometrial Mesenchymal Stem Cells That Survived Sublethal Heat Shock

A. E. Vinogradov | M. A. Shilina | ... | N. N. Nikolsky
  • Special Issue
  • - Volume 2017
  • - Article ID 4015039
  • - Review Article

The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche

Cosette M. Rivera-Cruz | Joseph J. Shearer | ... | Marxa L. Figueiredo
  • Special Issue
  • - Volume 2017
  • - Article ID 9209127
  • - Review Article

Regulatory Role of Redox Balance in Determination of Neural Precursor Cell Fate

Mohamed Ariff Iqbal | Eftekhar Eftekharpour
  • Special Issue
  • - Volume 2017
  • - Article ID 5706193
  • - Research Article

Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats

Jing Yang | Li Zhang | ... | Quanhai Li
  • Special Issue
  • - Volume 2017
  • - Article ID 4979474
  • - Research Article

The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction

Giulia Cheloni | Martina Poteti | ... | Persio Dello Sbarba
  • Special Issue
  • - Volume 2017
  • - Article ID 4276927
  • - Review Article

Environmental Factors That Influence Stem Cell Migration: An “Electric Field”

Stephanie N. Iwasa | Robart Babona-Pilipos | Cindi M. Morshead
  • Special Issue
  • - Volume 2017
  • - Article ID 8936156
  • - Review Article

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

Cristina D'Aniello | Federica Cermola | ... | Gabriella Minchiotti
  • Special Issue
  • - Volume 2017
  • - Article ID 5295286
  • - Review Article

Wnt5a Signaling in Normal and Cancer Stem Cells

Yan Zhou | Thomas J. Kipps | Suping Zhang
  • Special Issue
  • - Volume 2017
  • - Article ID 7859184
  • - Research Article

Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells

Taekhee Jung | John Hwan Lee | ... | Sun-Woong Kang
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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