Stem Cells International

Application of Stem Cells in Bone and Cartilage Regeneration


Publishing date
01 Oct 2018
Status
Published
Submission deadline
25 May 2018

Lead Editor

1Huazhong University of Science and Technology, Wuhan, China

2Guangzhou Medical University, Guangzhou City, China

3The George Washington University, Washington, USA

4The University of Hong Kong, Pok Fu Lam, Hong Kong

5University of Oxford, Oxford, UK

6The Hospital of the University of Pennsylvania, Philadelphia, USA


Application of Stem Cells in Bone and Cartilage Regeneration

Description

Stem cell is so noticeable for its great application prospect in many fields such as regenerative medicine, biomaterials science, geriatrics, and neuroscience. However, there is little research concentrating on the field of orthopedics relatively. With the development of multiagency tissue engineering science, stem cells are more and more important in orthopedics.

We all know the importance of tissue engineering in bony remodeling, bone repair, osteogenesis, and regeneration of degenerative disease. There were three key factors in tissue engineering including materials, cells, and cytokines. We pay close attention to the factor of “cells.” Beyond all question, stem cells is the optimal choice in this field for its excellent self-renewal ability, multiple differentiation potential, antiaging resistance, and availability. In orthopedics department, we receive many trauma patients with severe bone defect and fracture; we hope that osteoprogenitor cells can be reserved for bone repair. After all, the biological behaviour of stem cells is so important and needs more scientific research.

It is exciting that, with the deepening of research, more categories of mesenchymal stem cells were discovered. Intervertebral disc stem cells are one of the endogenous stem cells. These stem cells can be a potential target spot to put off the degeneration process of intervertebral disc and even take part in the process of regeneration in spine degenerative disease. Degenerative osteoarthritis is also a disease that causes severe economic burden and affects quality of life as well as intervertebral disc degeneration. Chondrostem cells are an extensive and in-depth study of endogenous mesenchymal stem cells and understanding the biological behavior, survival mode, differentiation potential and method of regulation and control of chondrostem cells may bring positive meaning of degenerative osteoarthritis.

It is worth mentioning that tumor stem cell is also a new field of bone tumor. Literature reports that osteosarcoma stem cells play an important role in tumor development and progression. Control methods of tumor stem cells and understanding their manner of death may provide a new way to find out the way of growth and mortality of tumor.

Although stem cells have been explored more, meaningful things need deeper research to demonstrate their magic. Stem cells have the ability of self-renewal, multidirectional differentiation, regeneration, and repair and these features determine their importance in degeneration disease and bone trauma. Bone tumor may also be controlled if tumour stem cells are studied more deeply. Therefore, we can predict that stem cells have broad prospect in orthopedics.

Potential topics include but are not limited to the following:

  • Recent development of stem cells in bone and cartilage regeneration
  • Signal regulation of stem cells
  • Application of stem cells in regeneration of cartilage
  • Application of stem cells in regeneration of bone

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 1201927
  • - Research Article

Characterization and Optimization of the Seeding Process of Adipose Stem Cells on the Polycaprolactone Scaffolds

Agata Kurzyk | Barbara Ostrowska | ... | Zygmunt Pojda
  • Special Issue
  • - Volume 2019
  • - Article ID 8914569
  • - Review Article

Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head

Yi Wang | Xibo Ma | ... | Jie Tian
  • Special Issue
  • - Volume 2018
  • - Article ID 7412304
  • - Review Article

Intervertebral Disc-Derived Stem/Progenitor Cells as a Promising Cell Source for Intervertebral Disc Regeneration

Binwu Hu | Ruijun He | ... | Zengwu Shao
  • Special Issue
  • - Volume 2018
  • - Article ID 1481243
  • - Research Article

Effect of Compression Loading on Human Nucleus Pulposus-Derived Mesenchymal Stem Cells

Hang Liang | Sheng Chen | ... | Zengwu Shao
  • Special Issue
  • - Volume 2018
  • - Article ID 2562105
  • - Research Article

Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway

Feng Jiao | Wang Tang | ... | Hui Ren
  • Special Issue
  • - Volume 2018
  • - Article ID 4258613
  • - Research Article

Osteogenic Potential of Human Umbilical Cord Mesenchymal Stem Cells on Coralline Hydroxyapatite/Calcium Carbonate Microparticles

A. G. E. Day | W. R. Francis | ... | Z. Xia
  • Special Issue
  • - Volume 2018
  • - Article ID 1943980
  • - Research Article

Very Small Embryonic-Like Stem Cells, Endothelial Progenitor Cells, and Different Monocyte Subsets Are Effectively Mobilized in Acute Lymphoblastic Leukemia Patients after G-CSF Treatment

Andrzej Eljaszewicz | Lukasz Bolkun | ... | Marcin Moniuszko
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication40 days
CiteScore3.800
Impact Factor3.902
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