Stem Cells International

Stem Cells and Nuclear Reprogramming


Publishing date
15 Aug 2011
Status
Published
Submission deadline
15 Feb 2011

Lead Editor

1Renova Life Inc., University of Maryland, College Park, MD 20742, USA

2Center for Regenerative Biology, University of Connecticut, Storrs, CT 06269, USA

3Istituto Superiore di Sanità (ISS), Rome, Italy

4Institute and Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan

5Department of Animal Science, National Pingtung University of Science and Technology, Pingtung, Taiwan


Stem Cells and Nuclear Reprogramming

Description

Stem cells are defined in functional terms as having both the ability to replenish themselves through cell division and the ability to differentiate into specialized cell types. Stem cells are found in all multicellular organisms, including two broadly-defined cell types: embryonic stem cells (ESCs) that are derived from the inner cell mass of blastocyst-stage embryos and adult stem cells that are present in adult tissues. Stem cells can now be grown and transformed in vitro into specialized cells with characteristics that are consistent with those of cell types found in various tissues, such as muscles or nerves. Highly plastic adult stem cells isolated from a variety of sources, including umbilical cord blood and bone marrow, are routinely used in medical therapies.

Nuclear reprogramming refers to the erasure and remodeling of epigenetic marks, such as DNA methylation, which is a part of normal mammalian development. After fertilization, the paternal and maternal genomes (excepting differentially methylated regions associated with imprinted genes) are demethylated and remethylated. This reprogramming is likely required for totipotency of the newly formed embryo and erasure of acquired epigenetic changes. In vitro manipulation of preimplantation embryos has been shown to disrupt methylation patterns at imprinted loci, and such disruption plays a crucial role in the development of cloned animals.

Advances in stem cells and nuclear reprogramming shall provide new insights into the mechanisms of cellular differentiation, during embryonic development as well as in adult tissues, and insights which may lead to therapies for several human diseases. The special issue will emphasize novel approaches for understanding mechanisms that underlie the phenomenon of stem cells derivation, reprogramming, and development. Potential topics include, but are not limited to:

  • Derivation of embryonic stem cells (ESCs)
  • Derivation of induced pluripotent stem (iPS) cells
  • Potentials of ESC and iPS for cell-based therapies
  • Somatic cell nuclear transfer (NT), stem cells derived from NT, and related reprogramming events
  • Epigenetics of stem cells
  • Adult stem cells, pluripotency, and applications

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/sci/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 584686
  • - Editorial

Stem Cells and Nuclear Reprogramming

Fuliang Du | Mark G. Carter | ... | Perng-Chih Shen
  • Special Issue
  • - Volume 2011
  • - Article ID 619583
  • - Review Article

Generation of Induced Pluripotent Stem (iPS) Cells by Nuclear Reprogramming

Dilip Dey | Gregory R. D. Evans
  • Special Issue
  • - Volume 2011
  • - Article ID 717069
  • - Research Article

Efficient Non-Viral Integration and Stable Gene Expression in Multipotent Adult Progenitor Cells

Andrew Wilber | Fernando Ulloa Montoya | ... | Uma Lakshmipathy
  • Special Issue
  • - Volume 2011
  • - Article ID 924782
  • - Research Article

Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling In Vitro

Reto Eggenschwiler | Komal Loya | ... | Tobias Cantz
  • Special Issue
  • - Volume 2011
  • - Article ID 425863
  • - Review Article

Nuclear Reprogramming in Mouse Primordial Germ Cells: Epigenetic Contribution

Massimo De Felici
  • Special Issue
  • - Volume 2011
  • - Article ID 570125
  • - Review Article

Preclinical Studies on Mesenchymal Stem Cell-Based Therapy for Growth Plate Cartilage Injury Repair

Rosa Chung | Bruce K. Foster | Cory J. Xian
  • Special Issue
  • - Volume 2011
  • - Article ID 795239
  • - Research Article

Expression Patterns of Cancer-Testis Antigens in Human Embryonic Stem Cells and Their Cell Derivatives Indicate Lineage Tracks

Nadya Lifantseva | Anna Koltsova | ... | Olga Gordeeva
  • Special Issue
  • - Volume 2011
  • - Article ID 201371
  • - Review Article

Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation

Chad M. Teven | Xing Liu | ... | Tong-Chuan He
  • Special Issue
  • - Volume 2011
  • - Article ID 907961
  • - Review Article

Technical Challenges in the Derivation of Human Pluripotent Cells

Parinya Noisa | Rangsun Parnpai
  • Special Issue
  • - Volume 2011
  • - Article ID 560261
  • - Review Article

Alternative Splicing in Self-Renewal of Embryonic Stem Cells

Clara Y. Cheong | Thomas Lufkin
Stem Cells International
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Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
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