Stem Cells International

Engineering Cell Systems


Publishing date
01 Mar 2019
Status
Published
Submission deadline
26 Oct 2018

Lead Editor

1Universidade de Lisboa, Lisbon, Portugal

2The Cell and Gene Therapy Catapult, London, UK

3CCRM, Toronto, Canada


Engineering Cell Systems

Description

Stem Cell Engineering is the application of engineering principles to understanding biological systems, solve biological problems, and ultimately contribute to the translation of new therapeutic approaches to clinical practice. Key technologies, such as novel bioprocesses for the maintenance and expansion of human stem cells, as well as their differentiated progeny, and micro-/nanofabrication to produce tissues-like substitutes, are gaining substantial attention. Other emerging topics include the development of cellular products based on innovative scaffolds for 3D cultivation of stem/progenitor cells, functional human tissue-like substitutes, and controlled-release particles to program the differentiation of stem cells. Furthermore, the development of in vitro tests for toxicity, cell differentiation, genomic stability of expanded cells, and biocompatibility can profit from these scientific and technological advancements. Finally, these technologies should be developed with the objective of being implemented under Good Manufacturing Practice (GMP) conditions, in order to facilitate their translation to the clinic.

This special issue aims to attract key original contributions related to human stem cell systems, namely, hematopoietic stem/progenitor, mesenchymal stem, vascular progenitor, embryonic stem, and induced pluripotent stem cells. Review articles describing the current state of the art are also encouraged and welcomed.

Potential topics include but are not limited to the following:

  • Methodologies to improve the basic understanding of the fundamental processes that control stem cell activity and their differentiation (Systems Biology and Engineering)
  • The design of specific motifs at different length scales to improve cell functionality and physiological responses of engineered cellular constructs (Niche Engineering)
  • Controlled-release systems to guide stem cell responses (Niche Engineering)
  • Technologies involved in derivation and isolation of stem cells from different sources (Bioprocessing)
  • Large-scale bioreactors and processes for the maintenance and expansion of long-term transplantable human stem cells, as well as their differentiated progeny, ensuring their availability for cell-based therapies (Bioprocessing)
  • Engineered scaffolds for 3D stem/progenitor cell culture and production of functional human tissue-like substitutes (Cell and Tissue Engineering)

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 4685137
  • - Editorial

Engineering Cell Systems

Tiago G. Fernandes | Ricardo P. Baptista | Howard Kim
  • Special Issue
  • - Volume 2019
  • - Article ID 8469012
  • - Research Article

Spontaneously Formed Spheroids from Mouse Compact Bone-Derived Cells Retain Highly Potent Stem Cells with Enhanced Differentiation Capability

Kai Chen | Xianqi Li | ... | Hideaki Kagami
  • Special Issue
  • - Volume 2019
  • - Article ID 4508470
  • - Review Article

Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering

Teresa P. Silva | João P. Cotovio | ... | Tiago G. Fernandes
  • Special Issue
  • - Volume 2019
  • - Article ID 9831853
  • - Review Article

Stimuli-Responsive Graphene Nanohybrids for Biomedical Applications

Dinesh K. Patel | Yu-Ri Seo | Ki-Taek Lim
  • Special Issue
  • - Volume 2019
  • - Article ID 7867613
  • - Research Article

In Vitro Cultivation of Limbal Epithelial Stem Cells on Surface-Modified Crosslinked Collagen Scaffolds

Michel Haagdorens | Vytautas Cėpla | ... | Marie-José Tassignon
  • Special Issue
  • - Volume 2019
  • - Article ID 8203950
  • - Review Article

Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation

Rosaria Santoro | Gianluca Lorenzo Perrucci | ... | Giulio Pompilio
  • Special Issue
  • - Volume 2019
  • - Article ID 8347595
  • - Research Article

Scalable Culture Strategies for the Expansion of Patient-Derived Cancer Stem Cell Lines

Ana Teresa Serra | Margarida Serra | ... | Paula M. Alves
  • Special Issue
  • - Volume 2019
  • - Article ID 9704945
  • - Research Article

Laminin as a Potent Substrate for Large-Scale Expansion of Human Induced Pluripotent Stem Cells in a Closed Cell Expansion System

Fernanda C. Paccola Mesquita | Camila Hochman-Mendez | ... | Doris A. Taylor
  • Special Issue
  • - Volume 2019
  • - Article ID 9671206
  • - Review Article

Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering

Haojiang Li | Shi Shen | ... | Quanyi Guo
  • Special Issue
  • - Volume 2018
  • - Article ID 7173481
  • - Research Article

Novel Calcium Phosphate Cement with Metformin-Loaded Chitosan for Odontogenic Differentiation of Human Dental Pulp Cells

Wei Qin | Jia-Yao Chen | ... | Hockin H. K. Xu
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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