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Directed Stem Cell Differentiation by Genetic and Bioengineering Tools

Call for Papers

One of the important challenges in stem cell research is robust stem cell differentiation with minimal heterogeneity and immaturity by employing reproducible, safe, biological, medical, and engineering tools. Cell differentiation is guided by their interaction with given microenvironment factors (outside-in signaling) as well as with their own genetic programing (inside-out signaling). Chemical, physical, and biological pathways operating phenotype changes resulting from strategic gene reprograming or from interaction with microenvironment are also of particular interest. For this reason, immense efforts have been put together to achieve this goal by converging various means from the fields of biology, medicine, and engineering. Recently, applications of stem cell modified by engineering tools have emerged as potentially therapeutic approaches to promote repair and regeneration of injured organs.

We will consider research articles covering the state-of-the-art genetic and bioengineering technologies that have been used for directing stem cell differentiation in the fields of stem cell engineering, genetic engineering, microfabrication, biomimetic topography on cellular mechanosensitivity, biosensitivity, and chemical sensitivity, and genetically engineered human stem cell models for various applications.

Additionally, the purpose of this special issue is to publish papers with high-quality research and review addressing recent advances on stem cell differentiation by genetic and bioengineering tools and therapeutic approaches using stem cell modified with gene and bioengineering tools in various diseases.

Potential topics include but are not limited to the following:

  • Genetic reprograming for stem cell differentiation
  • Nano- and microengineered biomimicry for stem cell differentiation
  • Chemical, physical, and biological pathways operating phenotype changes
  • Organ printing
  • Stem cell manufacturing
  • Improving stemness from aging
  • Stem cells as a cargo for therapeutic delivery
  • Stem cell engineering by genome editing
  • Therapeutic approaches using stem cells modified by engineering tools

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 3 November 2017
Publication DateMarch 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

  • Hee-Woo Lee, Seoul National University Hospital, Seoul, Republic of Korea

Guest Editors

  • Hak-Joon Sung, Vanderbilt University, Nashville, USA
  • Dong-Soo Lee, Seoul National University College of Medicine, Seoul, Republic of Korea
  • Geum Joon Cho, Korea University College of Medicine, Seoul, Republic of Korea
  • Xintong Wang, Revenue Analytics, Inc., Atlanta, USA