Stem Cells International

Base Modifications: Regulation of Stem Cell Functions and Diseases


Publishing date
01 Mar 2018
Status
Published
Submission deadline
03 Nov 2017

Lead Editor
Guest Editors

1Emory University, Atlanta, USA

2Zhejiang University, Zhejiang, China


Base Modifications: Regulation of Stem Cell Functions and Diseases

Description

Vast emerging evidences are addressing the crosstalk between base modifications and stem cell functions such as lineage commitment, specification, self-renewal, quiescence, proliferation, and differentiation. The base modifications dynamically occur in DNA and RNA, including 5-methylcytosine (5mC) and its oxidative derivatives (5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-caC)) and N6-methyladenosine (m6A) in DNA, 5-mC and m6A in mRNA; and modifications in other noncoding RNAs. The timely and spatially dynamic base modifications ensure quiescence, fate specification, proliferation, or differentiation in naturally programmed tracks during the life process.

In recent decade, significant progress has been made in appreciation of the link between aberrant base modifications in stem cells and diseases, like cancers, neurodegenerative disorders, and so on. These achievements are inspiring scientists to further uncover the epigenetic mechanisms for stem cell development and to dissect pathogenesis of the multiple diseases conferred by development aberration of the stem cells. This special issue will focus on the research advances in epigenetic regulation of stem cell pluripotency and multipotency and the diseases.

We invite investigators in the field of epigenetics in stem cells and the stem cells-related diseases such as neurodegenerative diseases, cardiac diseases, hematological diseases, and cancers to contribute original research articles as well as review articles that focus on addressing the role of nucleic acid modifications in the development of stem cell and genesis of disorders.

Potential topics include but are not limited to the following:

  • Novel techniques/methodologies for detection of nucleic acid modifications in stem cells
  • Epigenetic regulation of open chromatin in stem cells
  • Epigenetic basis of stem cell aging
  • Influence of metabolic pathways on epigenetic alteration associated with lineage commitment, specification, and self-renewal
  • Effects of DNA and/or RNA modifications on self-renewal, quiescence, activation of quiescence, proliferation, and differentiation of stem cells including embryonic stem cells and any specialized stem cells like neural stem cell, cardiac stem cells, hematopoietic stem cells, satellite stem cells, iPSC, and so on
  • Epigenetically incurred aberrant development of stem cells and the caused diseases including neurological disorders, hematological diseases, and cancers
  • Importance and significance of nucleic acid modifications as regulators in the development and diseases
  • Discovery of the epigenetic modifiers for stem cell therapy by using genetic analysis, bioinformatics, and biological tools

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5402384
  • - Editorial

Base Modifications: Regulation of Stem Cell Functions and Diseases

Yujing Li | Changwon Park | Xuekun Li
  • Special Issue
  • - Volume 2018
  • - Article ID 3256524
  • - Review Article

N6-Methyladenosine in RNA and DNA: An Epitranscriptomic and Epigenetic Player Implicated in Determination of Stem Cell Fate

Pengfei Ji | Xia Wang | ... | Yujing Li
  • Special Issue
  • - Volume 2018
  • - Article ID 7834175
  • - Review Article

Novel Epigenetic Techniques Provided by the CRISPR/Cas9 System

Nina Xie | Yafang Zhou | ... | Beisha Tang
  • Special Issue
  • - Volume 2018
  • - Article ID 6087143
  • - Review Article

Epigenetic Regulations in Neural Stem Cells and Neurological Diseases

Hang Zhou | Bin Wang | ... | Yongxiang Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 2186301
  • - Research Article

The Dynamic DNA Demethylation during Postnatal Neuronal Development and Neural Stem Cell Differentiation

Huikang Tao | Pei Xie | ... | Xuekun Li
  • Special Issue
  • - Volume 2017
  • - Article ID 6305295
  • - Review Article

Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy

Lin Cheng | Kun Zhang | ... | Tianmin Xu
  • Special Issue
  • - Volume 2017
  • - Article ID 8596135
  • - Research Article

The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5

Abdullah Shah | Farooq Rashid | ... | Ge Shan
  • Special Issue
  • - Volume 2017
  • - Article ID 5946527
  • - Research Article

Plasma Rich in Growth Factors Induces Cell Proliferation, Migration, Differentiation, and Cell Survival of Adipose-Derived Stem Cells

Maravillas Mellado-López | Richard J. Griffeth | ... | Victoria Moreno-Manzano
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication40 days
CiteScore3.800
Impact Factor3.902
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