Stem Cells International

Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine 2018


Publishing date
01 Nov 2018
Status
Published
Submission deadline
29 Jun 2018

Lead Editor

1University of Bari “Aldo Moro”, Bari, Italy

2City Unity College, Athens, Greece

3Université Pierre et Marie Curie, Paris, France

4Tecnologica Research Institute, Crotone, Italy


Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine 2018

Description

Mesenchymal stem cells (MSCs) are currently being tested in preclinical and clinical trials for their ability to foster wound healing and tissue regeneration. They are well known to show a therapeutic potential largely depending on their ability to secrete proregenerative cytokines, making these cells an attractive option for improving the treatment of chronic wounds. The wound microenvironment is a miscellaneous key-factor in the local management of the healing process: players such as the extracellular matrix or the resident and recruited cells with paracrine activity are able to determine the way and the appropriateness of the regenerative processes.

Dental-derived Mesenchymal Stem Cells (D-dMSCs) are an intriguing milestone of the regenerative medicine, with regards to their potential of differentiating into osteogenic, adipogenic and chondrogenic lineages.

Despite the multiple barriers to their clinical use, MSCs or D-dMSCs have shown sufficient promise to garner a primary place in the field of translational medicine. In fact, MSCs and D-dMSCs cell therapies have significant implications for human health: clinical studies are greatly needed to confirm or stimulate the basic and translational researches aimed to reach cutting-edge results.

In this special issue, we invite worldwide researchers as well as the clinicians confident in the regenerative medicine to submit their most interesting reviews and original papers describing the good, the bad, and the ugly of MSCs and D-dMSCs in translational medicine, wound healing and tissue regeneration.

Innovative aspects of MSCs and D-dMSCs and/or their biology, and other regenerative concepts, within the context of isolation, derivation, reprogramming, self-renewal, quality control, differentiation, transplantation, good manufacturing practice (GMP), new sources of D-dMSCs or MSCs, and other similar studies are warmly welcome topics.

Potential topics include but are not limited to the following:

  • Mesenchymal stem cells in translational research and therapeutic strategies towards tissue regeneration and wound healing
  • Computational models investigating the mechanobiology of MSCs/D-dMSCs and their interactions with scaffolds for tissue engineering
  • Bioinformatics and/or novel applications for Biomaterials, Scaffolds and Three-dimensional cell culture models to better understand MSCs biology
  • Growth factors effects on MSCs
  • MSCs activity and delivery/routes, extracellular matrix and bioactive molecules, inflammation/immunomodulation and mesenchymal stem cells activity
  • Clinical research on application of D-dMSCs or MSCs and their cross-talk with engineered peptide and protein Materials, including Bioengineered/Biomimetic scaffolds, secretome, feasibility and “proof-of-concept” studies
  • New methodological paradigms that challenge current thinking in clinical research, and development of clinical-grade MSCs/D-dMSCs in matrix remodeling under good manufacturing practice (GMP) protocols/conditions

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 6927401
  • - Editorial

Mesenchymal Stem Cells as Promoters, Enhancers, and Playmakers of the Translational Regenerative Medicine 2018

Andrea Ballini | Stefania Cantore | ... | Marco Tatullo
  • Special Issue
  • - Volume 2018
  • - Article ID 3069741
  • - Research Article

Therapeutic Effects of VEGF Gene-Transfected BMSCs Transplantation on Thin Endometrium in the Rat Model

Zhao Jing | Yan Yi | ... | Li Yanping
  • Special Issue
  • - Volume 2018
  • - Article ID 7162084
  • - Research Article

The Differential Effects of Leukocyte-Containing and Pure Platelet-Rich Plasma on Nucleus Pulposus-Derived Mesenchymal Stem Cells: Implications for the Clinical Treatment of Intervertebral Disc Degeneration

Jun Jia | Shan-zheng Wang | ... | Chen Wang
  • Special Issue
  • - Volume 2018
  • - Article ID 3290372
  • - Research Article

MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction

Teng Ma | Yueqiu Chen | ... | Zhenya Shen
  • Special Issue
  • - Volume 2018
  • - Article ID 4706943
  • - Research Article

GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells

Sonia Bergante | Pasquale Creo | ... | Luigi Anastasia
  • Special Issue
  • - Volume 2018
  • - Article ID 3208285
  • - Review Article

In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review

Mila Janjic | Denitsa Docheva | ... | Uwe Baumert
  • Special Issue
  • - Volume 2018
  • - Article ID 5402853
  • - Research Article

Osteogenic Effect and Cell Signaling Activation of Extremely Low-Frequency Pulsed Electromagnetic Fields in Adipose-Derived Mesenchymal Stromal Cells

Patrina S. P. Poh | Claudine Seeliger | ... | Martijn van Griensven
  • Special Issue
  • - Volume 2018
  • - Article ID 7146384
  • - Research Article

Treatment of Full-Thickness Rotator Cuff Tendon Tear Using Umbilical Cord Blood-Derived Mesenchymal Stem Cells and Polydeoxyribonucleotides in a Rabbit Model

Dong Rak Kwon | Gi-Young Park | Sang Chul Lee
  • Special Issue
  • - Volume 2018
  • - Article ID 9283432
  • - Research Article

Mathematical Modeling Reveals the Role of Hypoxia in the Promotion of Human Mesenchymal Stem Cell Long-Term Expansion

Shuhua Gao | Cheng Xiang | ... | Changkai Sun
  • Special Issue
  • - Volume 2018
  • - Article ID 1658195
  • - Research Article

Human Placenta-Derived Mesenchymal Stem Cells Reduce Mortality and Hematoma Size in a Rat Intracerebral Hemorrhage Model in an Acute Phase

Bo Young Choi | Ok Joon Kim | ... | Tae Nyoung Chung
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision78 days
Acceptance to publication41 days
CiteScore3.800
Impact Factor3.902
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