Stem Cells International

Regulation of Stemness in Carcinoma Cells


Status
Published

Lead Editor

1Western University of Health Sciences, California, USA

2Loma Linda University, California, USA

3Cedars Sinai Medical Center, California, USA

4Baylor College of Medicine, Texas, USA

5Osaka University, Osaka, Japan


Regulation of Stemness in Carcinoma Cells

Description

Over the last decade, our understanding of tumor heterogeneity and progression has steadily shifted from the traditional stochastic model, which postulated that all tumor cells have an equal probability of regrowing a malignancy, to a cancer stem cell (CSC) model in which recurrent and metastatic tumors are initiated by a subpopulation of cells with the ability to self-renew and differentiate. For many types of cancer, CSCs are thought to be responsible for metastasis, recurrence, and therapeutic resistance. Therefore, a better understanding of mechanisms underlying regulation of CSC’s stemness and biology will contribute toward development of more effective therapeutic approaches to eradicating cancer cells by targeting CSCs.

The purpose of this special issue is to provide a forum for high-quality research papers as well as review articles focusing on recent advances in CSC research. These articles will cover a range of topics that appeal to a broad readership. We therefore invite and encourage researchers to submit original relevant research articles and reviews that are not yet published or that are not currently under review by other journals.

Potential topics include but are not limited to the following:

  • Mechanisms in regulation of CSCs’ self-renewal
  • Mechanisms and methods to dedifferentiate/reprogram cancer cells to CSCs
  • Mechanisms and methods by which normal tissue stem cells are transdifferentiated into cancer cells and/or CSCs
  • Cross-talk between microenvironments and CSCs
  • miRNA in regulation of CSCs
  • Epigenetics in regulation of CSCs
  • Role of CSCs in cancer initiation, progression and metastasis
  • Role of CSCs in therapeutic resistance

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 7681769
  • - Editorial

Regulation of Stemness in Carcinoma Cells

Jijun Hao | Juli Unternaehrer | ... | Yusuke Oji
  • Special Issue
  • - Volume 2017
  • - Article ID 8629234
  • - Review Article

Prostate Cancer Stem Cell Markers Drive Progression, Therapeutic Resistance, and Bone Metastasis

Koran S. Harris | Bethany A. Kerr
  • Special Issue
  • - Volume 2017
  • - Article ID 2480375
  • - Review Article

An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma

Alexander J. Hron | Atsushi Asakura
  • Special Issue
  • - Volume 2017
  • - Article ID 5619472
  • - Review Article

Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment

Pedro M. Aponte | Andrés Caicedo
  • Special Issue
  • - Volume 2017
  • - Article ID 3684178
  • - Review Article

Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells

Gregory M. Kelly | Mohamed I. Gatie
  • Special Issue
  • - Volume 2017
  • - Article ID 2925869
  • - Review Article

Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment

Jeffrey Koury | Li Zhong | Jijun Hao
  • Special Issue
  • - Volume 2017
  • - Article ID 3714190
  • - Review Article

Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications

Eunice Yuen-Ting Lau | Nicole Pui-Yu Ho | Terence Kin-Wah Lee
  • Special Issue
  • - Volume 2016
  • - Article ID 2059584
  • - Research Article

Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45

Xianghe Song | Danni Liu | ... | Zongjin Li
Stem Cells International
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Acceptance rate44%
Submission to final decision83 days
Acceptance to publication49 days
CiteScore3.800
Impact Factor3.902
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