Stem Cells International

Targeted Strategies to Modulate Stem-Cell-Relevant Pathways


Publishing date
05 Aug 2016
Status
Published
Submission deadline
18 Mar 2016

1Marian University, Indianapolis, USA

2University of Iowa, Iowa City, USA

3Kyushu Dental University, Fukuoka, Japan

4University of Sydney, Newtown, Australia


Targeted Strategies to Modulate Stem-Cell-Relevant Pathways

Description

Modulation of stem cell differentiation is of significant interest to the biomedical community and could lead to novel therapeutic advances in treating disease. Achieving this goal requires specific strategies that manipulate the pathways regulating stem cell plasticity and behavior. The accumulating evidence indicates that just a few main signaling pathways regulate most types of stem cells, which suggests that strategies that modulate one type of stem cell might hold broad usefulness. However, as stem cell research becomes more and more specialized, investigators studying a particular pathway in one specialty can miss a breakthrough advancement made in another specialty. Thus, the aim of this special issue is to take a pathway-focused approach to detail strategies—both proven and theoretical—that modulate the activity of stem-cell-relevant pathways (such as Wnt, TGF-beta, BMP, Notch, and FGF). We hope this special issue will advance the larger stem cell field by providing pathway-focused content including cutting-edge original research articles and accessible in-depth reviews that bridge investigators studying the same pathway in multiple stem cell populations.

Potential topics include, but are not limited to:

  • Recombinant agonists or antagonists
  • Engineered agonists/antagonists
  • Gene transfer approaches
  • Chemical agonists or antagonists
  • Neutralizing antibodies
  • Decoy receptors
  • Engineered cell-based systems

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 1859456
  • - Editorial

Targeted Strategies to Modulate Stem-Cell-Relevant Pathways

Jonathan W. Lowery | James A. Ankrum | ... | Renjing Liu
  • Special Issue
  • - Volume 2016
  • - Article ID 3826249
  • - Research Article

High-Fidelity Reprogrammed Human IPSCs Have a High Efficacy of DNA Repair and Resemble hESCs in Their MYC Transcriptional Signature

Pratik K. Nagaria | Carine Robert | ... | Feyruz V. Rassool
  • Special Issue
  • - Volume 2016
  • - Article ID 7290686
  • - Review Article

A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future Perspectives

Jonathan W. Lowery | Brice Brookshire | Vicki Rosen
  • Special Issue
  • - Volume 2016
  • - Article ID 1406304
  • - Research Article

Disrupted Endothelial Cell Layer and Exposed Extracellular Matrix Proteins Promote Capture of Late Outgrowth Endothelial Progenitor Cells

Jing Zhao | Claudia-Gabriela Mitrofan | ... | Andrew M. L. Lever
  • Special Issue
  • - Volume 2016
  • - Article ID 6289825
  • - Review Article

Mesenchymal Stem Cells after Polytrauma: Actor and Target

Markus Huber-Lang | Rebecca Wiegner | ... | Rolf E. Brenner
  • Special Issue
  • - Volume 2016
  • - Article ID 3753581
  • - Review Article

Cell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells

Shoichiro Kokabu | Jonathan W. Lowery | Eijiro Jimi
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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