Stem Cells International

Transcriptional and Genomic Control of Stem Cells in Development and Cancer


Status
Published

Lead Editor

1Saint Louis University, St. Louis, USA

2Far Eastern Memorial Hospital, New Taipei City, Taiwan

3University of Cincinnati, Cincinnati, USA

4University of Texas Health Science Center, Houston, USA

5MD Anderson Cancer Center, Houston, USA


Transcriptional and Genomic Control of Stem Cells in Development and Cancer

Description

Stem cells play important roles in development and cancer. Whereas “normal” stem cells are capable of differentiating into functional cell types during development, the “malignant” form, known as cancer stem cells, is involved in cancer progression and recurrence. Cancer stem cells have lost their ability to differentiate but maintain the ability to undergo self-renewal. Both transcriptional and genomic pathways play important roles in ensuring the normal function of stem cells. At the transcriptional level, sequence-specific transcription factors and coregulators work together to orchestrate the transcriptional landscape of stem cells, which determines the on/off state of target genes, thereby controlling the cell fate of stem cells. At the genomic level, the replication and repair machineries maintain the genomic stability of stem cells. Defects in any of these processes can convert normal stem cells into the malignant form, which ultimately leads to cancer and leukemia.

Regulations of transcription, chromatin remodeling, and genomic instability are at the forefront of contemporary stem cell research. While protein factors are well-known regulators of these processes, noncoding RNAs have recently emerged as a unique class of stem cell modulators. In addition, new technologies such as next-generation sequencing and transcriptome profiling have become important tools in studying the function and regulation of stem cells. This special issue is devoted to the rapid advancements in these areas.

We invite investigators to contribute original research articles as well as review articles that will stimulate and provide new insight into our understanding of the genomic function and regulation of stem cells.

Potential topics include but are not limited to the following:

  • Regulation and function of normal and diseased stem cells
  • Mechanisms of transcriptional and epigenetic regulation of stem cell function
  • Novel function of transcription factors, corepressors, and coactivators
  • Characterization of histone modifications and modifying enzymes
  • Role of noncoding RNAs
  • Novel bioinformatic methods for analyzing the cistrome and transcriptome of stem cells
  • Genome instability of stem cells
  • Origin of cancer and leukemia stem cells
  • Cross talk between genetic and epigenetic factors in stem cell regulation and function

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2513598
  • - Editorial

Transcriptional and Genomic Control of Stem Cells in Development and Cancer

Jinsong Zhang | Chien-Hung Gow | ... | Chuanwei Yang
  • Special Issue
  • - Volume 2017
  • - Article ID 1651325
  • - Research Article

Resveratrol Induces Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Neuron-Like Cells

Li Guo | Liang Wang | ... | De-Pei Li
  • Special Issue
  • - Volume 2017
  • - Article ID 5091541
  • - Research Article

Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer

Chuanwei Yang | Xuemei Zhao | ... | Yulong Liang
  • Special Issue
  • - Volume 2017
  • - Article ID 8916570
  • - Review Article

Mesenchymal Stem Cell Administration in Patients with Chronic Obstructive Pulmonary Disease: State of the Science

Shih-Lung Cheng | Ching-Hsiung Lin | Chao-Ling Yao
  • Special Issue
  • - Volume 2017
  • - Article ID 5274171
  • - Research Article

β-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest

Agnese Po | Federica Begalli | ... | Evelina Miele
  • Special Issue
  • - Volume 2017
  • - Article ID 6962379
  • - Review Article

Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia

Mengning Wang | Chuanwei Yang | ... | Dale G. Schaar
  • Special Issue
  • - Volume 2017
  • - Article ID 1610691
  • - Review Article

Regulation of Stem Cell Properties of Müller Glia by JAK/STAT and MAPK Signaling in the Mammalian Retina

Krista M. Beach | Jianbo Wang | Deborah C. Otteson
  • Special Issue
  • - Volume 2017
  • - Article ID 2412890
  • - Review Article

Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke

Le Zhang | Wenjing Tao | ... | Yujie Chen
  • Special Issue
  • - Volume 2016
  • - Article ID 4810734
  • - Review Article

Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects

Shiwu Zhang | Dan Zhang | ... | Xipeng Zhang
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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