Stem Cells International

Stem Cells for Cartilage Regeneration: A Roadmap to the Clinic


Status
Published

Lead Editor

1Novartis Institutes for Biomedical Research Basel, Basel, Switzerland

2Osaka University, Osaka, Japan

3Orthopaedic Arthroscopic Surgery International (O.A.S.I.) Bioresearch Foundation, Milan, Italy

4University of Milan, Milan, Italy


Stem Cells for Cartilage Regeneration: A Roadmap to the Clinic

Description

The clinical utility of stem and stromal cells has been proposed for the repair and regeneration of the articular surface although a broad clinical adoption of stem cell-based cartilage repair strategies has been limited. Recently, cells from different cell sources have been used in clinical trials with different approaches, while iPS cells started to show promises for cartilage regeneration in preclinical studies. The need for more translational animal models and reliable biomarkers arose from these important experiences. Last but not least, the optimal delivery system (e.g., hydrogel, scaffold) still needs to be identified.

The purpose of this special issue is to publish high-quality research articles as well as reviews that seek to address recent development on the use of stem cells for cartilage regeneration, as well as the relevant prospect on opportunities and challenges. In particular, we would like to cover the various aspects that are crucial for a successful clinical translation and identify the key hurdles that still remain to be overcome.

Potential topics include but are not limited to the following:

  • Mesenchymal stromal/stem cells from various sources: in vivo cartilage regeneration, transcriptomic and epigenetic signatures, and clinical potential
  • Translational clinical trial cartilage regeneration: innovative study designs and preliminary results
  • Translational animal models for stem cell-based cartilage regeneration studies: small versus large animal models
  • Application of pharmacologic strategies to promote stem cell-based cartilage repair: harnessing the potential of endogenous progenitor cells
  • Autologous and allogeneic stem cells: how to promote tolerance and streamline the clinical adoption of allogeneic therapies for cartilage repair; cell labelling to track progenitor cells upon implantation
  • Intervertebral disk regeneration: potential for cell-based therapies, need for dedicated delivery systems, the role of biomaterials, notochordal cells, and role of hypoxia
  • Bioreactors for basic and clinical studies: requirements for clinical application of bioreactor technologies
  • Noninvasive biomarkers discovery to monitor the cartilage repair activity of progenitor cells: the role of soluble biomarkers and of advanced imaging

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7348560
  • - Editorial

Stem Cells for Cartilage Regeneration: A Roadmap to the Clinic

Celeste Scotti | Alberto Gobbi | ... | Giuseppe M. Peretti
  • Special Issue
  • - Volume 2018
  • - Article ID 8431053
  • - Research Article

Production of Adult Human Synovial Fluid-Derived Mesenchymal Stem Cells in Stirred-Suspension Culture

Kristen D. Jorgenson | David A. Hart | ... | Arindom Sen
  • Special Issue
  • - Volume 2018
  • - Article ID 8490489
  • - Review Article

Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration

Yoojun Nam | Yeri Alice Rim | ... | Ji Hyeon Ju
  • Special Issue
  • - Volume 2018
  • - Article ID 5102630
  • - Research Article

Regeneration of Tracheal Tissue in Partial Defects Using Porcine Small Intestinal Submucosa

Nelson Bergonse Neto | Lianna Ferrari Jorge | ... | Luiz Cesar Guarita-Souza
  • Special Issue
  • - Volume 2018
  • - Article ID 6594841
  • - Review Article

Translational Application of Microfluidics and Bioprinting for Stem Cell-Based Cartilage Repair

Silvia Lopa | Carlotta Mondadori | ... | Matteo Moretti
  • Special Issue
  • - Volume 2018
  • - Article ID 9079538
  • - Review Article

Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures

Melissa Lo Monaco | Greet Merckx | ... | Ivo Lambrichts
  • Special Issue
  • - Volume 2018
  • - Article ID 9432616
  • - Research Article

Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells

Yeri Alice Rim | Yoojun Nam | ... | Ji Hyeon Ju
  • Special Issue
  • - Volume 2017
  • - Article ID 7053465
  • - Research Article

Successful Low-Cost Scaffold-Free Cartilage Tissue Engineering Using Human Cartilage Progenitor Cell Spheroids Formed by Micromolded Nonadhesive Hydrogel

Mellannie P. Stuart | Renata A. M. Matsui | ... | Leandra S. Baptista
  • Special Issue
  • - Volume 2017
  • - Article ID 2761678
  • - Review Article

The Application of Stem Cells from Different Tissues to Cartilage Repair

James N. Fisher | Irene Tessaro | ... | Laura Mangiavini
  • Special Issue
  • - Volume 2017
  • - Article ID 5979741
  • - Review Article

Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis

Dixin Cui | Hongyu Li | ... | Yachuan Zhou
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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