Stem Cells International

Biomedical Applications of Dental and Oral-Derived Stem Cells


Status
Published

Lead Editor

1University of Hong Kong, Pokfulam, Hong Kong

2Peking University, Beijing, China

3Queensland University of Technology, Brisbane, Australia

4University of Modena and Reggio Emilia, Modena, Italy

5University of Minnesota, Minneapolis, USA

6University of Zurich, Zurich, Switzerland


Biomedical Applications of Dental and Oral-Derived Stem Cells

Description

Over the past decade, a diverse array of adult stem cells has been identified within the oral cavity. These include dental pulp stem cells (DPSCs), dental follicle stem cells (DFSCs), stem cells from apical papilla (SCAP), stem cells from human exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), and mesenchymal stem cells from the gingiva (GMSCs). A major advantage of these adult stem cells is their ease of isolation from readily available biological waste routinely produced during dental treatment, that is, extraction of impacted third molars (i.e., wisdom tooth) and deciduous tooth (i.e., primary tooth).

While the overwhelming majority of previous studies have demonstrated that these adult stem cells certainly have useful applications in various dental treatments (i.e., periodontal and maxillofacial regeneration, osseous integration of titanium implants, and dental pulp regeneration after endodontic treatment), a number of studies have emerged which suggest that such stem cells also have much potential for diverse nondental medical applications. It was positively demonstrated in various animal models that dental and oral-derived stem cells could be utilized for bone, cartilage, and tendon regeneration, repair of spinal cord injury and peripheral nerve regeneration, enhancement of angiogenesis and healing of skin wounds, and even aiding in recovery of heart function after acute myocardial infarction. Similar to BM-MSCs, dental and oral-derived adult stem cells have also been shown to possess immunomodulatory properties that can be exploited for cell-based therapy of immune and inflammation-related diseases.

We hereby invite researchers in both the dental and medical fields to contribute original research articles as well as review articles that will deepen our understanding of the biological characteristics and functionality of dental and oral-derived stem cells, together with their applications in cell-based therapy.

Potential topics include, but are not limited to:

  • Basic research on the transcriptome, secretome, and proteomic profile of dental and oral-derived adult stem cells
  • The utilization of these adult stem cells for cell-based therapy in both dentistry and medicine
  • Novel biomaterial scaffolds for these adult stem cells
  • The immune-modulatory properties of these adult stem cells, and their application in cell-based therapy of immune and inflammation-related diseases
  • Nontherapeutic applications of these adult stem cells in toxicology, pharmacology, and in vitro disease modeling

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2931054
  • - Editorial

Biomedical Applications of Dental and Oral-Derived Stem Cells

Boon Chin Heng | Chengfei Zhang | ... | Thimios A. Mitsiadis
  • Special Issue
  • - Volume 2016
  • - Article ID 7695836
  • - Review Article

Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application

Qian Zhu | Qiqi Lu | ... | Tong Cao
  • Special Issue
  • - Volume 2016
  • - Article ID 7231038
  • - Review Article

Innovative Dental Stem Cell-Based Research Approaches: The Future of Dentistry

Shayee Miran | Thimios A. Mitsiadis | Pierfrancesco Pagella
  • Special Issue
  • - Volume 2016
  • - Article ID 8905365
  • - Research Article

Innate Immune Response of Human Embryonic Stem Cell-Derived Fibroblasts and Mesenchymal Stem Cells to Periodontopathogens

Gopu Sriram | Vaishali Prakash Natu | ... | Tong Cao
  • Special Issue
  • - Volume 2016
  • - Article ID 5957806
  • - Review Article

Pluripotency of Stem Cells from Human Exfoliated Deciduous Teeth for Tissue Engineering

Vinicius Rosa | Nileshkumar Dubey | ... | Jacques E. Nör
  • Special Issue
  • - Volume 2016
  • - Article ID 8307195
  • - Review Article

Dental and Nondental Stem Cell Based Regeneration of the Craniofacial Region: A Tissue Based Approach

Declan Hughes | Bing Song
  • Special Issue
  • - Volume 2016
  • - Article ID 3454876
  • - Research Article

XPC Promotes Pluripotency of Human Dental Pulp Cells through Regulation of Oct-4/Sox2/c-Myc

Lu Liu | Zhengjun Peng | ... | Xi Wei
  • Special Issue
  • - Volume 2016
  • - Article ID 6240794
  • - Research Article

Scaffold-Free Fabrication of Osteoinductive Cellular Constructs Using Mouse Gingiva-Derived Induced Pluripotent Stem Cells

Hiroko Okawa | Hiroki Kayashima | ... | Hiroshi Egusa
  • Special Issue
  • - Volume 2016
  • - Article ID 3453890
  • - Research Article

Genetic Comparison of Stemness of Human Umbilical Cord and Dental Pulp

Chung-Min Kang | Hyunok Kim | ... | Hyung-Jun Choi
  • Special Issue
  • - Volume 2016
  • - Article ID 9762465
  • - Review Article

Biomedical Application of Dental Tissue-Derived Induced Pluripotent Stem Cells

Jung-Hwan Lee | Seog-Jin Seo
Stem Cells International
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