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Ca2+ Signaling during Stem Cell Differentiation

Call for Papers

Understanding the regulation of stem cell proliferation and differentiation is essential for these cells to be developed into effective clinical therapies. The calcium ion (Ca2+) is recognized as a ubiquitous second messenger for conveying information from one cell to another as well as across individual cells, from the exterior to the interior and via specific subcellular compartments. There is clear evidence that Ca2+ helps to regulate key aspects of the cellular events that occur in developing embryos. As many features of embryonic cell differentiation are recapitulated during the differentiation of stem cells, it is therefore not surprising that reports are now accumulating that describe the involvement of Ca2+ in the regulation of stem cell differentiation.

For this special issue, we invite researchers from a wide range of disciplines to share their knowledge by contributing original research articles, as well as review articles. The manuscripts submitted should be of high quality and should emphasize the role of Ca2+ signaling in stem cell differentiation with a focus on the putative upstream signaling events and the possible downstream targets. Articles on extracellular, intercellular, intracellular, and both intra- and interorganellar Ca2+ signals are also encouraged along with attempts to integrate these localized aspects into complex signaling cascades.

Potential topics include but are not limited to the following:

  • Intra-, inter-, and/or extracellular Ca 2+ signaling during stem cell differentiation
  • Intra- and/or interorganellar Ca2+ signaling (i.e., within/between the nucleus, ER, mitochondria, and/or lysosomes)
  • SOCE and stem cell differentiation
  • Ca2+ signaling and regeneration
  • Ca2+ signaling and the regulation of gene expression in stem cells
  • Ca2+ signaling and autophagy
  • Advances in methodologies for imaging Ca2+ in stem cells
  • Assessing Ca2+ signaling modulators as potential drugs to promote the further development of stem cell-based therapies
  • Interaction between Ca2+ signaling and other signaling pathways (e.g., notch and Wnt) in stem cells
  • Ca2+ signaling and epigenetics in stem cells

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 6 April 2018
Publication DateAugust 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

  • Andrew L. Miller, Hong Kong University of Science & Technology, Kowloon, Hong Kong

Guest Editors