Stem Cells International

Mesenchymal Stem Cell Biodistribution, Migration, and Homing In Vivo


Publishing date
02 Aug 2013
Status
Published
Submission deadline
15 May 2013

Lead Editor

1Departments of Biomedical Engineering and of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, and Chao Family Comprehensive Cancer Center, University of California, Irvine, CA 92967, USA

2Department of Molecular Therapeutics, Scripps Florida, Jupiter, FL 33458, USA

3Haematopoietic Stem Cell Laboratory, Cancer Research UK, Lincoln's Inn Fields Laboratories, London Research Institute, London, UK

4Laboratory of Cell Biology and Advanced Cancer Therapies, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia, 41100 Modena, Italy

5Section of Hematology, Stem Cell Research Laboratory and Cell Factory and Department of Medicine, University of Verona, Policlinico G.B. Rossi, Piazzale L.A., 37126 Verona, Italy


Mesenchymal Stem Cell Biodistribution, Migration, and Homing In Vivo

Description

Culture-expanded mesenchymal stem cells (MSCs), also known as multipotent mesenchymal stromal cells, are emerging therapeutics being tested in over 200 ongoing clinical trials to treat a variety of inflammatory, ischemic, and neurologic diseases. However, many questions pertaining to the biodistribution of transplanted MSCs, the molecular mechanism that promote their migration to diseased/injured tissues, and if homing is prerequisite for cells to exert their therapeutic effects remain unresolved. In fact, it is a subject of debate whether MSCs localize to tissue due to passive entrapment in small vessels, particularly in lung, or if cells employ active mechanisms similar to leukocytes to home to specific tissues. Therefore, continued study into the mechanism that regulate trafficking of endogenous and transplanted MSCs will shed novel insight into basic MSC biology, and lead to the development of more potent cell-based therapies.

We invite investigators to contribute original research articles that will facilitate our understanding of the biodistribution, migration, and homing of endogeneous and/or transplanted MSCs in vivo. We are particularly interested in articles that focus on mechanistic studies in vivo. Potential topics include, but are not limited to:

  • Biodistribution and kinetics of engraftment and clearance of transplanted MSCs in vivo
  • Mechanisms of MSC homing to sites of inflammation, injury and tumors in vivo (i.e., role of adhesion molecules, chemokine receptors, MMPs, etc.)
  • Mobilization of endogeneous MSCs in response to injury
  • Mechanism regulating intravasation/extravasation of endogenous or transplanted MSCs in vivo
  • Is MSC homing to the target site a requirement to treat a disease?
  • Improved/novel techniques to monitor MSC trafficking/biodistribution in vivo
  • Enhancing MSC homing via engineering approaches

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/sci/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/sci/dmh/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 292109
  • - Editorial

Mesenchymal Stem Cell Biodistribution, Migration, and Homing In Vivo

Weian Zhao | Donald G. Phinney | ... | Mauro Krampera
  • Special Issue
  • - Volume 2014
  • - Article ID 939275
  • - Research Article

Long-Term Quantitative Biodistribution and Side Effects of Human Mesenchymal Stem Cells (hMSCs) Engraftment in NOD/SCID Mice following Irradiation

Sabine François | Benoit Usunier | ... | Alain Chapel
  • Special Issue
  • - Volume 2013
  • - Article ID 678063
  • - Review Article

Biodistribution of Mesenchymal Stem/Stromal Cells in a Preclinical Setting

Luc Sensebé | Sandrine Fleury-Cappellesso
  • Special Issue
  • - Volume 2013
  • - Article ID 130763
  • - Review Article

Mesenchymal Stem Cells Migration Homing and Tracking

Abhishek Sohni | Catherine M. Verfaillie
  • Special Issue
  • - Volume 2013
  • - Article ID 983059
  • - Review Article

Cellular Kinetics of Perivascular MSC Precursors

William C. W. Chen | Tea Soon Park | ... | Bruno Péault
  • Special Issue
  • - Volume 2013
  • - Article ID 732742
  • - Review Article

MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation

Thomas J. Kean | Paul Lin | ... | James E. Dennis
  • Special Issue
  • - Volume 2013
  • - Article ID 435093
  • - Review Article

From Blood to the Brain: Can Systemically Transplanted Mesenchymal Stem Cells Cross the Blood-Brain Barrier?

Linan Liu | Mark A. Eckert | ... | Weian Zhao
  • Special Issue
  • - Volume 2013
  • - Article ID 582527
  • - Clinical Study

Intracoronary Infusion of Autologous CD133+ Cells in Myocardial Infarction and Tracing by Tc99m MIBI Scintigraphy of the Heart Areas Involved in Cell Homing

Ubaidullo Kurbonov | Abdusamad Dustov | ... | Massoud Mirshahi
  • Special Issue
  • - Volume 2013
  • - Article ID 892065
  • - Research Article

Hepatocyte Growth Factor-Loaded Biomaterials for Mesenchymal Stem Cell Recruitment

Julia van de Kamp | Willi Jahnen-Dechent | ... | Sabine Neuss
  • Special Issue
  • - Volume 2013
  • - Article ID 656839
  • - Research Article

Dynamic Imaging of Marrow-Resident Granulocytes Interacting with Human Mesenchymal Stem Cells upon Systemic Lipopolysaccharide Challenge

Jay T. Myers | Deborah S. Barkauskas | Alex Y. Huang
Stem Cells International
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Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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