Stem Cells International

Epigenetic Regulation of Stem Cell Fate


Publishing date
01 Dec 2020
Status
Closed
Submission deadline
24 Jul 2020

Lead Editor

1Sichuan University, Chengdu, China

2Sun Yat-Sen University, Guangzhou, China

3Anhui Medical University, Hefei, China

This issue is now closed for submissions.
More articles will be published in the near future.

Epigenetic Regulation of Stem Cell Fate

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The development, homeostasis, and regeneration of tissues and organs depend on stem cells and their proper fate commitment. Epigenetic regulation plays a key role in cell fate determination, including totipotent, pluripotent, multipotent, or differentiated cells. It regulates the transcriptional and translational dynamics of stem cells without altering their genetic sequence. It functions through different mechanisms, such as histone and DNA modification, genomic imprinting, noncoding RNAs, and RNA editing. Growing clinical and laboratory studies have reported pathological conditions resulted from compromised cell differentiation trajectory in the context of epigenetic dysregulation.

It is therefore necessary to elucidate the epigenetic control on stem cell fate. Recent advances have unraveled some epigenetic factors on stem cell identity and plasticity. Examples include the contribution of dynamic chromatin to embryonic stem cell differentiation and overall organism development, messenger RNA chemical modification (e.g. N6-methyladenosine, N1-methyladenosine, 5-methylcytosine) on hematopoietic, spermatogonial, mesenchymal and cancer stem cell fate decision, and transfer RNA and ribosomal RNA modification on neural development and disorder. However, the epigenetic mechanism of stem cells remains largely unexplored.

This Special Issue invites researchers to contribute original research and review articles discussing the epigenetic control of stem cell fate in development and tissue homeostasis, and its role in the pathogenesis and advances in epigenetic-based strategies to restore normal cellular identity.

Potential topics include but are not limited to the following:

  • New insights into chromatin plasticity from cellular heterogeneity and cell identity during development and throughout life. Topics should be restricted to DNA modifications, histone variants, chaperones and heterochromatin factors, etc.
  • Chemical modifications and protein kinases important for messenger RNA processing and maturation, and their regulation on stem cell fate commitment and diseases
  • Translational control of cellular identity by non-coding RNAs and ribosomal RNAs
  • Technique advances to capture the transient and specialized transcriptional landscape in individual stem cell differentiation
  • Construction of an in vitro cellular model for epigenetic control on differentiation trajectory
  • Characterization of cellular identity with epigenetic indicators
  • Therapeutic strategies based on epigenetic cues to reverse stem cell fate and improve treatment outcome

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 8888416
  • - Research Article

Chaetocin Promotes Osteogenic Differentiation via Modulating Wnt/Beta-Catenin Signaling in Mesenchymal Stem Cells

Youde Liang | Xin Liu | ... | Weiwei Xue
  • Special Issue
  • - Volume 2020
  • - Article ID 8876265
  • - Review Article

Epigenetic Regulation of Dental Pulp Stem Cell Fate

Dan Zhou | Lu Gan | ... | Wei Du
  • Special Issue
  • - Volume 2020
  • - Article ID 8890917
  • - Review Article

Small Molecule Epigenetic Modulators in Pure Chemical Cell Fate Conversion

Zhao-Di Yuan | Wei-Ning Zhu | ... | Yan-Chuang Han
  • Special Issue
  • - Volume 2020
  • - Article ID 8882857
  • - Research Article

CHD7 Regulates Osteogenic Differentiation of Human Dental Follicle Cells via PTH1R Signaling

Caojie Liu | Qiwen Li | ... | Ning Kang
  • Special Issue
  • - Volume 2020
  • - Article ID 8852313
  • - Review Article

Identification of Molecular Signatures in Neural Differentiation and Neurological Diseases Using Digital Color-Coded Molecular Barcoding

Debora Salerno | Alessandro Rosa
  • Special Issue
  • - Volume 2020
  • - Article ID 8836258
  • - Review Article

Epigenetic Regulation in Mesenchymal Stem Cell Aging and Differentiation and Osteoporosis

Ruoxi Wang | Yu Wang | ... | Weiran Li
  • Special Issue
  • - Volume 2020
  • - Article ID 8839703
  • - Review Article

ATP-Dependent Chromatin Remodeling Complex in the Lineage Specification of Mesenchymal Stem Cells

Wen Du | Daimo Guo | Wei Du
  • Special Issue
  • - Volume 2020
  • - Article ID 8860185
  • - Research Article

Histone Demethylase KDM4C Is Required for Ovarian Cancer Stem Cell Maintenance

Guo-Qing Chen | Ping Ye | ... | Xiao-Ying Xie
  • Special Issue
  • - Volume 2020
  • - Article ID 8877577
  • - Research Article

Bmi1 Severs as a Potential Tumor-Initiating Cell Marker and Therapeutic Target in Esophageal Squamous Cell Carcinoma

Xiaochen Wang | Kang Li | ... | Demeng Chen
  • Special Issue
  • - Volume 2020
  • - Article ID 8897138
  • - Research Article

Ascorbic Acid, Inflammatory Cytokines (IL-1β/TNF-α/IFN-γ), or Their Combination’s Effect on Stemness, Proliferation, and Differentiation of Gingival Mesenchymal Stem/Progenitor Cells

Karim M. Fawzy El-Sayed | Nhung Nguyen | Christof E. Dörfer
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
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Impact Factor5.443
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.