Stem Cells International

Noncoding RNAs and Stem Cell Function and Therapy


Status
Published

Lead Editor

1Augusta University, Augusta, USA

2Guangdong Medical University, Zhanjiang, China

3Wright State University, Dayton, USA

4Shanghai University of Traditional Chinese Medicine, Shanghai, China

5Shanghai Jiao Tong University, Shanghai, China


Noncoding RNAs and Stem Cell Function and Therapy

Description

Pluripotent stem cells, such as embryonic stem cells and induced pluripotent cells, can differentiate into any tissues from three germ layers, and resident stem cells in adult tissue are responsible for tissue maintenance and internal repair.

Previous studies on the stem cells have been dominated by protein paradigms. Recent advances have provided compelling evidence that noncoding RNAs, such as microRNAs (miRNA), long noncoding RNAs (lncRNA), circular RNAs (circRNA), Piwi-interacting RNA (piRNA), small nucleolar RNAs (snoRNAs), and others, play a critical role in fine regulation of gene expression by transcriptional and posttranscriptional mechanisms. It is also becoming increasingly evident that both small noncoding RNAs and long noncoding RNAs (LncRNAs) have a profound impact on the stem cell fate determination, including differentiation, apoptosis, autophagy, proliferation, and integration; therefore, noncoding RNAs have attracted a lot of attention for their potential in stem cell therapy.

This special issue welcomes research as well as review articles that provide the emerging importance of noncoding RNAs in stem cell function and therapy.

Potential topics include but are not limited to the following:

  • Functions of noncoding RNAs in stem/progenitor cell differentiation
  • Functions of noncoding RNAs in stem cell reprogramming and pluripotency
  • Functions of noncoding RNAs in stem cell apoptosis, autophagy, and proliferation
  • Improving stem cell therapy in tissue regeneration using noncoding RNA
  • Noncoding RNA mediated epigenetic mechanism for stem cell fate determination
  • Cellular signaling related to noncoding RNA regulation
  • Biomaterials and tissue engineering using noncoding RNA modified stem cells
  • Role of noncoding RNA in stem cell derived exosomes

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7306034
  • - Editorial

Noncoding RNAs and Stem Cell Function and Therapy

Yaoliang Tang | Wei Lei | ... | Mi Zhou
  • Special Issue
  • - Volume 2018
  • - Article ID 7494530
  • - Research Article

MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells

Can Chen | Quanxiang Yan | ... | Wei Lei
  • Special Issue
  • - Volume 2017
  • - Article ID 4252974
  • - Research Article

Long Noncoding RNA uc001pwg.1 Is Downregulated in Neointima in Arteriovenous Fistulas and Mediates the Function of Endothelial Cells Derived from Pluripotent Stem Cells

Lei Lv | Haozhe Qi | ... | Lan Zhang
  • Special Issue
  • - Volume 2017
  • - Article ID 9012152
  • - Research Article

Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a

Qian Cheng | Xin Li | ... | Jing Liu
  • Special Issue
  • - Volume 2017
  • - Article ID 1096980
  • - Research Article

Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury

Yu Zhou | Panpan Chen | ... | Jian-An Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 6825427
  • - Review Article

Noncoding RNA and Cardiomyocyte Proliferation

Shuang Qu | Chunyu Zeng | Wei Eric Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 9495739
  • - Research Article

Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-Benzopyrene/Angiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm

Yingying Zhou | Jiaoni Wang | ... | Kangting Ji
  • Special Issue
  • - Volume 2017
  • - Article ID 1719050
  • - Review Article

Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes

Alejandro Luarte | Pablo Cisternas | ... | Roberto Henzi
  • Special Issue
  • - Volume 2017
  • - Article ID 6374504
  • - Review Article

Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation

Seahyoung Lee | Hyang-Hee Seo | ... | Ki-Chul Hwang
  • Special Issue
  • - Volume 2017
  • - Article ID 1769298
  • - Research Article

miR-142-3p Contributes to Early Cardiac Fate Decision of Embryonic Stem Cells

Zhong-Yan Chen | Fei Chen | ... | Huang-Tian Yang
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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