Stem Cells International

Developing Stem Cell-Based Therapeutic Strategies in Orthopaedic Surgery


Status
Published

Lead Editor

1University of Manitoba, Winnipeg, Canada

2Hiroshima University, Hiroshima, Japan

3University of Bologna, Bologna, Italy

4Cleveland Clinic, Cleveland, USA

5Western University, London, Canada


Developing Stem Cell-Based Therapeutic Strategies in Orthopaedic Surgery

Description

Tissue engineering and regenerative approaches for the treatment of orthopaedic pathologies using stem cell-based strategies are on the verge of influencing clinical practice depending on the outcomes of widespread applications in ongoing basic research and clinical trials.

Freshly isolated Connective Tissue Progenitors (CTP), Endothelial Progenitor Cells (EPC), and culture expanded Mesenchymal Stem Cells (MSC) appear to be the three main cell types that the investigations have focused on to date. Cells derived from bone, bone marrow, cartilage, and adipose have all been shown to have potential applications for the repair and regeneration of musculoskeletal tissues.

This special issue will lay out and discuss the current concepts and present ground-breaking developments in stem cell-based treatment strategies in the field of orthopaedic surgery. We are soliciting high quality clinical and basic science original research articles as well as systematic review articles that focus on the use of stem cell-based therapies in orthopaedic surgery.

Potential topics include but are not limited to the following:

  • Results from pilot trials or completed clinical trials relevant to the use of stem cell-based treatments in humans with orthopaedic pathologies
  • Clinical human or larger animal basic research focusing on the most effective source, isolation, delivery, and tracking methods of stem/progenitor cells
  • Nomenclature, definition, and identification of stem/progenitor cells with potential applications for humans
  • Biological mechanisms that regulate behavior, including the timing and reasons for lineage commitment of stem/progenitor cells in native environment or posttransplant sites
  • Long-term safety of stem cell-based treatments in humans

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 5704192
  • - Editorial

Developing Stem Cell-Based Therapeutic Strategies in Orthopaedic Surgery

Kivanc Atesok | Mitsuo Ochi | ... | Meir Liebergall
  • Special Issue
  • - Volume 2018
  • - Article ID 6025918
  • - Research Article

A Multicentric, Open-Label, Randomized, Comparative Clinical Trial of Two Different Doses of Expanded hBM-MSCs Plus Biomaterial versus Iliac Crest Autograft, for Bone Healing in Nonunions after Long Bone Fractures: Study Protocol

Enrique Gómez-Barrena | Norma G. Padilla-Eguiluz | ... | Fabio Catani
  • Special Issue
  • - Volume 2018
  • - Article ID 7564159
  • - Research Article

Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats

Weiheng Wang | Yang Wang | ... | Xiaojian Ye
  • Special Issue
  • - Volume 2018
  • - Article ID 6542198
  • - Research Article

Mesenchymal Stem Cells in Oriented PLGA/ACECM Composite Scaffolds Enhance Structure-Specific Regeneration of Hyaline Cartilage in a Rabbit Model

Weimin Guo | Xifu Zheng | ... | Quanyi Guo
  • Special Issue
  • - Volume 2017
  • - Article ID 8154569
  • - Research Article

Therapeutic Potential of Multilineage-Differentiating Stress-Enduring Cells for Osteochondral Repair in a Rat Model

Elhussein Elbadry Mahmoud | Naosuke Kamei | ... | Mitsuo Ochi
  • Special Issue
  • - Volume 2017
  • - Article ID 3674045
  • - Research Article

Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach

Donatella Granchi | Enrique Gómez-Barrena | ... | Gabriela Ciapetti
  • Special Issue
  • - Volume 2017
  • - Article ID 1609685
  • - Review Article

Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects

Henning Madry | Liang Gao | ... | Magali Cucchiarini
  • Special Issue
  • - Volume 2017
  • - Article ID 7923826
  • - Research Article

Delayed Endothelial Progenitor Cell Therapy Promotes Bone Defect Repair in a Clinically Relevant Rat Model

Brent D. Bates | Charles Godbout | ... | Aaron Nauth
  • Special Issue
  • - Volume 2017
  • - Article ID 1960804
  • - Review Article

The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues

Naosuke Kamei | Kivanc Atesok | Mitsuo Ochi
  • Special Issue
  • - Volume 2017
  • - Article ID 1919845
  • - Review Article

Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application

Katie Joanna Lee | Peter David Clegg | ... | Elizabeth Gail Canty-Laird
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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