Stem Cells International

Cellular and Molecular Mechanisms of Mesenchymal Stem Cell Actions


Status
Published

Lead Editor

1University Hospital, Leipzig, Germany

2Institut Germans Trias de Recerca en Salut (IGTP), Badalona, Spain

3Université catholique de Louvain, Brussels, Belgium

4Erasmus MC-University Medical Center Rotterdam, Rotterdam, Netherlands

5University Hospital Regensburg, Regensburg, Germany


Cellular and Molecular Mechanisms of Mesenchymal Stem Cell Actions

Description

Cell therapy approaches using mesenchymal stem cells (MSC) for the treatment of both chronic and acute immune and degenerative diseases gain more and more clinical attention. This is not surprising, since MSC have proven immunomodulatory and regenerative properties and might be isolated from most tissues investigated so far in sufficient quality and quantity without any obvious risk for the donor or ethical constraints afflicted with other types of stem cells, for example, embryonic stem cells. However, these advantages also harbour imponderables associated with MSC intended for use in the clinics. It is now clear that MSC from different tissue and organ sources may feature similar phenotypic characteristics like capacity of plastic adherence, multiple differentiation potential, and surface marker profiles, the minimal definition criteria for MSC. But, gaining knowledge of molecular signatures by global gene expression, analyses currently reveal that heterogeneity exists between different MSC populations depending on their origin, isolation, and propagation procedures and on their status of differentiation.

It is also now very obvious that the major mode of actions mediated by MSC is not that much direct impacts like functional and/or architectural substitution of tissue loss, but rather paracrine or cellular mechanisms supporting self-restoration of the diseased tissue or organ. These mechanisms, however, are still poorly defined. Since MSC display pleiotropic properties like modulation of immune responses, alleviation of inflammation, and progress of tissue damage as well as stimulation of tissue regeneration, to unequivocally elucidate the molecular and cellular impact of a defined MSC population on a specified disease environment before their clinical application will be the goal of future efforts using relevant cell or animal model systems.

This special issue invites basic research and clinical investigators to share their knowledge by contributing original research as well as review articles emphasizing the detailed description of the cellular and molecular mechanisms of MSC action. These might particularly comprise global analyses using omics technologies to unravel genetic, expressional, and metabolic signatures of native or differentiated MSC of different origins and priming for application to specified disease conditions, both experimental and clinical, to delineate the impact of MSC action on a pathological tissue environment but also the impact of disease conditions of variable pathologies on MSC biology and action.

Potential topics include but are not limited to the following:

  • Molecular definition of MSC
  • Global analyses of MSC molecular signatures
  • Engineering of MSC for targeted actions
  • Molecular mechanisms of MSC trafficking
  • Therapy-tailored priming/licensing of MSC
  • Model systems for analysis of MSC mechanisms of action

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 2489041
  • - Editorial

Cellular and Molecular Mechanisms of Mesenchymal Stem Cell Actions

Bruno Christ | Marcella Franquesa | ... | Marc Hendrik Dahlke
  • Special Issue
  • - Volume 2017
  • - Article ID 8076529
  • - Review Article

Mesenchymal Stem Cell Benefits Observed in Bone Marrow Failure and Acquired Aplastic Anemia

Vivian Fonseca Gonzaga | Cristiane Valverde Wenceslau | ... | Irina Kerkis
  • Special Issue
  • - Volume 2017
  • - Article ID 6720594
  • - Review Article

Mesenchymal Stem Cells in Myeloid Malignancies: A Focus on Immune Escaping and Therapeutic Implications

Nicola Stefano Fracchiolla | Bruno Fattizzo | Agostino Cortelezzi
  • Special Issue
  • - Volume 2017
  • - Article ID 9717353
  • - Research Article

Mesenchymal Stromal Cells Accelerate Epithelial Tight Junction Assembly via the AMP-Activated Protein Kinase Pathway, Independently of Liver Kinase B1

P. Rowart | P. Erpicum | ... | F. Jouret
  • Special Issue
  • - Volume 2017
  • - Article ID 3282656
  • - Research Article

Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy

Bruno Solano de Freitas Souza | Kátia Nunes da Silva | ... | Milena Botelho Pereira Soares
  • Special Issue
  • - Volume 2017
  • - Article ID 1653254
  • - Review Article

Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential

Beata Kocan | Aleksandra Maziarz | ... | Agnieszka Banaś-Ząbczyk
  • Special Issue
  • - Volume 2017
  • - Article ID 8492797
  • - Research Article

Intrinsic Variability Present in Wharton’s Jelly Mesenchymal Stem Cells and T Cell Responses May Impact Cell Therapy

Fernanda Vieira Paladino | Luiz Roberto Sardinha | ... | Anna Carla Goldberg
  • Special Issue
  • - Volume 2017
  • - Article ID 2352954
  • - Research Article

Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study

Steffen Hartleif | Michael Schumm | ... | Ekkehard Sturm
  • Special Issue
  • - Volume 2017
  • - Article ID 5251313
  • - Review Article

Roles of Mesenchymal Stem Cells in Spinal Cord Injury

Jing Qu | Huanxiang Zhang
  • Special Issue
  • - Volume 2017
  • - Article ID 8178643
  • - Research Article

PGE2 Promotes the Migration of Mesenchymal Stem Cells through the Activation of FAK and ERK1/2 Pathway

Xiaomin Lu | Jibin Han | ... | Haibo Qiu
Stem Cells International
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Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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