Table of Contents Author Guidelines Submit a Manuscript

Novel Approaches to Understanding and Targeting of Cancer Stem Cells

Call for Papers

The success of current standard and targeted therapies is cancer type dependent. Cancer recurrence initiated by hibernating cells that remain intact and are not susceptible to the available treatments is the major cause of morbidity. The origin of these cancer initiating cells and/or cancer stem like cells (CSCs) is debated widely with studies supporting both hierarchical and stochastic models. The ambiguity in cancer stem cell theories arises mainly due to the lack of a complete set of markers that clearly define the hierarchy of cancer stem cells and reliable techniques to assess clonal expansion. The exploration for novel techniques as well as molecular signatures is imminent.

Owing to setbacks in understanding cancer stem cell origin and detailed molecular profiles, the targeting of these cells is restricted to multidrug resistant inhibitors and embryonic cell proliferation and differentiation pathways including Smo/Hedgehog and Wnt/-catenin. While high-throughput screening for drugs resulted in identification of targeting agents for cancer stem cells, for example, Salinomycin, much has not been translated to the clinic. Recent developments showcase the use of surface specific markers and manipulation of tumor microenvironment along with immunotherapies for cancer stem cell directed targeting. Even these need a precise understanding of molecular mechanistic signatures of cancer and cancer stem cells in the evolution of tumour.

More insights into the cancer stem cell origin and techniques to understand the cancer evolutionary mechanisms and targeting would be of great interest to researchers in various disciplines, including cancer biology, stem cell biology, drug development and delivery, molecular signalling pathways, evolution, developmental biology, gerontology, and other related fields. A deeper understanding of these issues will also enable a more targeted approach to cure cancer initiation, recurrence, and metastasis. This special issue is open to both original research articles and review articles.

Potential topics include but are not limited to the following:

  • Molecular signalling pathways of cancer and cancer stem cells
  • In vitro and in vivo models of cancer stem cells
  • Novel approaches to understand cancer stem cell origin and development
  • Identification of new targeting agents for cancer stem cells
  • Approaches to deliver cancer stem cell specific drugs and intervening mechanisms for cancer recurrence
  • Biomaterial mediated therapies to target cancer stem cells
  • Role of epithelial-to-mesenchymal transition in determining the cancer stem cell marker fate
  • Immunomodulatory effects of cancer stem cells and targeted therapies
  • Role of angiogenesis and tumour microenvironment in cancer stem cell proliferation and differentiation
  • Organ/tissue specific cancer stem cells markers and their role in determining disease progression and morbidity

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 13 July 2018
Publication DateNovember 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

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