Stem Cells International

Factors Regulating Stem Cell Biology in Development and Disease


Status
Published

Lead Editor

1University Tübingen, Tübingen, Germany

2University of Ulm, Ulm, Germany

3University of Pennsylvania, Philadelphia, USA

4Division of Experimental Hematology & Cancer Biology, Cincinnati, USA

5Technische Universität München, Munich, Germany


Factors Regulating Stem Cell Biology in Development and Disease

Description

One of the major characteristics of stem cells is the ability to divide symmetrically, the so-called self‐renewal. Genes preserving stem cell identify are termed “stem cell factors.” Although the most prominent pluripotent stem cell factors are comprised by the Yamanaka factors, other genes such as Nanog or Tbx3 play crucial roles in maintaining the pluripotency circuitry. However, such “stem cell factors” not only ensure stem cell function but also play so far underestimated roles.

First, recent reports suggest that “stem cell factors” fulfill additional functions during the stepwise phases of cell lineage commitment. For instance, during germ layer formation, Oct4 and Tbx3 promote mesodermal and endodermal fate and limit neuroectoderm differentiation potential. In contrast, Sox2 enhances neuroectoderm specification while restricting mesoderm and endoderm lineage development. Later, these factors are subsequently involved in tissue development.

Second, one hallmark of cancer is the ability to reactivate genetic programs known from early development and stem cells. Interestingly, signaling cascades regulating early patterning in the embryo such as Nodal signaling are again overexpressed during cancer development, and “stem cell factors” can drive dysplasia and tumorigenesis suggesting an intimate link between embryonic cell fate decisions, stem cells, and tumor development. In this special issue, we welcome review and original papers focusing on alternate functions of “stem cell factors” playing a role in disease but also during cell fate determination.

Additionally, we encourage reports on “disease specific genes” and their role in preserving stem cell identity as well as on new factors regulating cancer stem cell identity.

Potential topics include, but are not limited to:

  • New stem cell factors
  • Expression patterns of stem cell factors
  • Impact of stem cell factors on cell differentiation and function
  • Disease specific genes and their role in preserving stem cell identity
  • New factors regulating cancer stem cell identity

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 7170642
  • - Editorial

Factors Regulating Stem Cell Biology in Development and Disease

Stefan Liebau | Paul Gadue | ... | Alexander Kleger
  • Special Issue
  • - Volume 2015
  • - Article ID 218518
  • - Research Article

A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence

Georg Kuales | Matthias Weiss | ... | Sebastian J. Arnold
  • Special Issue
  • - Volume 2016
  • - Article ID 1520136
  • - Research Article

Exogenous Heparan Sulfate Enhances the TGF-β3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-β/Smad Signaling

Juan Chen | Yongqian Wang | ... | Caixia Xu
  • Special Issue
  • - Volume 2016
  • - Article ID 5646384
  • - Review Article

Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns

Kourosch C. Elahi | Gerd Klein | ... | Wilhelm K. Aicher
  • Special Issue
  • - Volume 2016
  • - Article ID 6838253
  • - Review Article

Pluripotency Factors on Their Lineage Move

Clair E. Weidgang | Thomas Seufferlein | ... | Martin Mueller
  • Special Issue
  • - Volume 2016
  • - Article ID 9076823
  • - Research Article

Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants

Katharina Nothelfer | Florian Obermayr | ... | Lothar Just
  • Special Issue
  • - Volume 2016
  • - Article ID 6759343
  • - Research Article

TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells

Moritz Klingenstein | Stefanie Raab | ... | Leonhard Linta
  • Special Issue
  • - Volume 2016
  • - Article ID 3710836
  • - Research Article

Three-Dimensional Gastrointestinal Organoid Culture in Combination with Nerves or Fibroblasts: A Method to Characterize the Gastrointestinal Stem Cell Niche

Agnieszka Pastuła | Moritz Middelhoff | ... | Michael Quante
  • Special Issue
  • - Volume 2016
  • - Article ID 5272498
  • - Research Article

NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation

Elisabeth Hessmann | Jin-San Zhang | ... | Alexander Koenig
  • Special Issue
  • - Volume 2016
  • - Article ID 9695827
  • - Research Article

Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells

Peter Helmut Neckel | Roland Mohr | ... | Lothar Just
Stem Cells International
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Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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