Stem Cells International

Current Status and Perspectives of Human Mesenchymal Stem Cell Therapy 2020


Publishing date
01 Sep 2020
Status
Closed
Submission deadline
08 May 2020

Lead Editor

1The University of British Columbia, Vancouver, Canada

2University of Alberta, Edmonton, Canada

3University of Malaya, Kuala Lumpur, Malaysia

This issue is now closed for submissions.
More articles will be published in the near future.

Current Status and Perspectives of Human Mesenchymal Stem Cell Therapy 2020

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Human mesenchymal stem cells (hMSCs) hold tremendous potential in cell-based therapies and regenerative medicine. Utilizing hMSCs could eliminate the ethical and safety concerns related to the use of other types of stem cells, including human embryonic stem cells and human induced pluripotent stem cells. hMSCs can be isolated from various tissues, including bone marrow, fat, amniotic fluid and umbilical cord, etc. hMSCs are capable of differentiating from the major specialized cells of the tissue in which they resided, therefore helping to repair and regenerate damaged tissues and organs. With its regenerative and curative potential, hMSCs have been studied in numerous clinical settings, including musculoskeletal, vascular, respiratory, and cardiac diseases, etc. Nonetheless, while the outcomes of numerous preclinical and clinical studies support the potential of hMSCs in various clinical fields, multiple challenges are yet to be addressed to achieve successful clinical translations.

In view of the growing need for hMSCs, this issue aims to discuss the recent advances on the use of hMSCs in various clinical settings, which will help us to better understand their therapeutic impact. It is also essential to understand all the steps required in developing stem cell therapy, including bioprocessing, safety and efficacy assessment, cell administration route and delivery strategies. This will aid in establishing strategies to maximize the therapeutic efficacy of hMSCs.

This Special Issue invites researchers, industrials, biomedical engineers, technologists, and healthcare professionals specialized in cell and molecular biology, regenerative medicine, and biotechnology to share their knowledge by contributing original basic and applied research articles, clinical studies, and review articles.

Potential topics include but are not limited to the following:

  • Mesenchymal stem cell therapy for musculoskeletal diseases
  • Mesenchymal stem cell therapy for vascular diseases
  • Mesenchymal stem cell therapy for respiratory diseases
  • Mesenchymal stem cell therapy for cardiac diseases
  • Bioprocessing of hMSCs, e.g., cryopreservation, cell expansion, or cell differentiation
  • Evaluation of different delivery strategies and administration routes of hMSCs
  • Strategies to improve the safety and efficacy of hMSCs

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 8894168
  • - Research Article

Medications for Hypertension Change the Secretome Profile from Marrow Stromal Cells and Peripheral Blood Monocytes

Nikunj Satani | Kaavya Giridhar | ... | Sean I. Savitz
  • Special Issue
  • - Volume 2020
  • - Article ID 5701920
  • - Review Article

Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials

Baocheng Xie | Minyi Chen | ... | Shaobo Ding
  • Special Issue
  • - Volume 2020
  • - Article ID 8813447
  • - Review Article

Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy

Jasmin S. Nurković | Radiša Vojinović | Zana Dolićanin
  • Special Issue
  • - Volume 2020
  • - Article ID 8878412
  • - Research Article

Galectin-3 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Reduces Aberrant Tau Phosphorylation in an Alzheimer Disease Model

Hoon Lim | Dahm Lee | ... | Dong Hyun Kim
  • Special Issue
  • - Volume 2020
  • - Article ID 9529465
  • - Review Article

Large-Scale Expansion of Human Mesenchymal Stem Cells

Muhammad Najib Fathi Bin Hassan | Muhammad Dain Yazid | ... | Jia Xian Law
  • Special Issue
  • - Volume 2020
  • - Article ID 8842659
  • - Research Article

The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration

Dragana Miloradovic | Dragica Miloradovic | ... | Vladislav Volarevic
  • Special Issue
  • - Volume 2020
  • - Article ID 8867115
  • - Research Article

The Role of Caspase-4 and NLRP1 in MCF7 Cell Pyroptosis Induced by hUCMSC-Secreted Factors

Yang Jiao | Linlin Wang | ... | Bingrong Zheng
  • Special Issue
  • - Volume 2020
  • - Article ID 8838046
  • - Review Article

Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases

Deqiang Han | Xin Zheng | ... | Zhiguo Chen
  • Special Issue
  • - Volume 2020
  • - Article ID 5684250
  • - Research Article

Screening and Functional Pathway Analysis of Pulmonary Genes Associated with Suppression of Allergic Airway Inflammation by Adipose Stem Cell-Derived Extracellular Vesicles

Sung-Dong Kim | Shin Ae Kang | ... | Hwan-Jung Roh
  • Special Issue
  • - Volume 2020
  • - Article ID 8237197
  • - Research Article

Extensive Characterization of Mesenchymal Stem Cell Marker Expression on Freshly Isolated and In Vitro Expanded Human Adipose-Derived Stem Cells from Breast Cancer Patients

Premrutai Thitilertdecha | Visnu Lohsiriwat | ... | Nattawat Onlamoon
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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