Stem Cells International

Current Status and Perspectives of Human Mesenchymal Stem Cell Therapy 2020


Publishing date
01 Sep 2020
Status
Published
Submission deadline
08 May 2020

Lead Editor

1The University of British Columbia, Vancouver, Canada

2University of Alberta, Edmonton, Canada

3University of Malaya, Kuala Lumpur, Malaysia


Current Status and Perspectives of Human Mesenchymal Stem Cell Therapy 2020

Description

Human mesenchymal stem cells (hMSCs) hold tremendous potential in cell-based therapies and regenerative medicine. Utilizing hMSCs could eliminate the ethical and safety concerns related to the use of other types of stem cells, including human embryonic stem cells and human induced pluripotent stem cells. hMSCs can be isolated from various tissues, including bone marrow, fat, amniotic fluid and umbilical cord, etc. hMSCs are capable of differentiating from the major specialized cells of the tissue in which they resided, therefore helping to repair and regenerate damaged tissues and organs. With its regenerative and curative potential, hMSCs have been studied in numerous clinical settings, including musculoskeletal, vascular, respiratory, and cardiac diseases, etc. Nonetheless, while the outcomes of numerous preclinical and clinical studies support the potential of hMSCs in various clinical fields, multiple challenges are yet to be addressed to achieve successful clinical translations.

In view of the growing need for hMSCs, this issue aims to discuss the recent advances on the use of hMSCs in various clinical settings, which will help us to better understand their therapeutic impact. It is also essential to understand all the steps required in developing stem cell therapy, including bioprocessing, safety and efficacy assessment, cell administration route and delivery strategies. This will aid in establishing strategies to maximize the therapeutic efficacy of hMSCs.

This Special Issue invites researchers, industrials, biomedical engineers, technologists, and healthcare professionals specialized in cell and molecular biology, regenerative medicine, and biotechnology to share their knowledge by contributing original basic and applied research articles, clinical studies, and review articles.

Potential topics include but are not limited to the following:

  • Mesenchymal stem cell therapy for musculoskeletal diseases
  • Mesenchymal stem cell therapy for vascular diseases
  • Mesenchymal stem cell therapy for respiratory diseases
  • Mesenchymal stem cell therapy for cardiac diseases
  • Bioprocessing of hMSCs, e.g., cryopreservation, cell expansion, or cell differentiation
  • Evaluation of different delivery strategies and administration routes of hMSCs
  • Strategies to improve the safety and efficacy of hMSCs

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 9801358
  • - Editorial

Current Status and Perspectives of Human Mesenchymal Stem Cell Therapy 2020

Jane Ru Choi | Kar Wey Yong | Hui Yin Nam
  • Special Issue
  • - Volume 2020
  • - Article ID 8877003
  • - Research Article

High Dose of Intravenous Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells (CLV-100) Infusion Displays Better Immunomodulatory Effect among Healthy Volunteers: A Phase 1 Clinical Study

Sze-Piaw Chin | Mohd-Yusoff Mohd-Shahrizal | ... | Soon Keng Cheong
  • Special Issue
  • - Volume 2020
  • - Article ID 8857344
  • - Research Article

Generation of Inducible CRISPRi and CRISPRa Human Stromal/Stem Cell Lines for Controlled Target Gene Transcription during Lineage Differentiation

Li Chen | Kaikai Shi | ... | Moustapha Kassem
  • Special Issue
  • - Volume 2020
  • - Article ID 5385960
  • - Research Article

Mechanical Strain-Mediated Tenogenic Differentiation of Mesenchymal Stromal Cells Is Regulated through Epithelial Sodium Channels

Hui Yin Nam | Malliga Raman Murali | ... | Tunku Kamarul
  • Special Issue
  • - Volume 2020
  • - Article ID 8889379
  • - Research Article

Small Extracellular Vesicles from Human Fetal Dermal Cells and Their MicroRNA Cargo: KEGG Signaling Pathways Associated with Angiogenesis and Wound Healing

Cinzia Maria Chinnici | Giandomenico Amico | ... | Pier Giulio Conaldi
  • Special Issue
  • - Volume 2020
  • - Article ID 8837654
  • - Review Article

Mesenchymal Stem/Progenitor Cells: The Prospect of Human Clinical Translation

Dina Rady | Marwa M. S. Abbass | ... | Karim M. Fawzy El-Sayed
  • Special Issue
  • - Volume 2020
  • - Article ID 8894168
  • - Research Article

Medications for Hypertension Change the Secretome Profile from Marrow Stromal Cells and Peripheral Blood Monocytes

Nikunj Satani | Kaavya Giridhar | ... | Sean I. Savitz
  • Special Issue
  • - Volume 2020
  • - Article ID 5701920
  • - Review Article

Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials

Baocheng Xie | Minyi Chen | ... | Shaobo Ding
  • Special Issue
  • - Volume 2020
  • - Article ID 8813447
  • - Review Article

Corneal Stem Cells as a Source of Regenerative Cell-Based Therapy

Jasmin S. Nurković | Radiša Vojinović | Zana Dolićanin
  • Special Issue
  • - Volume 2020
  • - Article ID 8878412
  • - Research Article

Galectin-3 Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Reduces Aberrant Tau Phosphorylation in an Alzheimer Disease Model

Hoon Lim | Dahm Lee | ... | Dong Hyun Kim
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.