Stem Cells International

Interaction between Stem Cells and the Microenvironment for Musculoskeletal Repair


Publishing date
01 Sep 2019
Status
Published
Submission deadline
03 May 2019

Lead Editor
Guest Editors

1Peking University Shenzhen Hospital, Shenzhen, China

2AO Research Institute Davos, Davos, Switzerland

3Rush University, Chicago, USA

4South China University of Technology, Guangzhou, China


Interaction between Stem Cells and the Microenvironment for Musculoskeletal Repair

Description

Stem cell-based approaches for musculoskeletal repair using in vitro experiments or animal models have been extensively investigated and have demonstrated substantial tissue repair capacity; however, the number of stem cell-based therapies translated for clinical practice is limited and the clinical outcomes are mixed. Stem cells/progenitors have been shown to interact with the microenvironment during in vitro expansion, as well as the surrounding host microenvironment after transplantation using various delivery systems; these interactions play a crucial role in the regulation of cellular viability, migration, differentiation, secretion, and other biological potential. The in vitro and in vivo microenvironment is defined by the cells resident within the niche, the extracellular matrix, the cytokine, and chemokine milieu, as well as dynamic changes in nutrient availability. Importantly, these microenvironmental elements vary considerably across tissues (bone, cartilage, intervertebral disc, tendon, periosteum, etc.) and by the homeostasis and pathological state of the native tissue; understanding of how candidate stem/progenitor cells respond to these unique environments and whether/how they change the tissue microenvironment is limited to a few recent studies. A thorough understanding of stem cell-microenvironment communication would therefore accelerate the success of musculoskeletal repair.

The importance of the microenvironment to the application of stem cell-based tissue repair strategies is increasingly being recognized as a significant regulator of stem cell behavior and its repair effect within musculoskeletal tissue. This Special Issue aims to collect both original research articles and reviews that improve the understanding of the behavior of transplanted cells and their impact on the local tissue environment. This Special Issue welcomes original research articles and reviews on this area of research

Potential topics include but are not limited to the following:

  • Interaction between stem cells and musculoskeletal extracellular matrix
  • Interaction between stem cells and musculoskeletal cells
  • Influence of local nutrients and biomechanical stimuli of musculoskeletal tissues on stem cell behavior
  • Role of cytokines and chemokines in stem cell-based therapeutics for musculoskeletal repair

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 7587428
  • - Editorial

Interaction between Stem Cells and the Microenvironment for Musculoskeletal Repair

Yong-Can Huang | Zhen Li | ... | Feng-Juan Lyu
  • Special Issue
  • - Volume 2019
  • - Article ID 7378594
  • - Research Article

Reactivation of Denervated Schwann Cells by Embryonic Spinal Cord Neurons to Promote Axon Regeneration and Remyelination

Xinyu Fang | Chaofan Zhang | ... | Wenming Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 4242178
  • - Research Article

Strontium Promotes the Proliferation and Osteogenic Differentiation of Human Placental Decidual Basalis- and Bone Marrow-Derived MSCs in a Dose-Dependent Manner

Yi-Zhou Huang | Cheng-Guang Wu | ... | Yong-Can Huang
  • Special Issue
  • - Volume 2019
  • - Article ID 3674647
  • - Review Article

Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading

Chuanxin Zhang | Jun Zhu | ... | James H-C. Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 8928934
  • - Review Article

Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis

Tao Zhou | Yuqing Yang | ... | Liang Xie
  • Special Issue
  • - Volume 2019
  • - Article ID 2376172
  • - Review Article

Interaction between Mesenchymal Stem Cells and Intervertebral Disc Microenvironment: From Cell Therapy to Tissue Engineering

Gianluca Vadalà | Luca Ambrosio | ... | Vincenzo Denaro
  • Special Issue
  • - Volume 2019
  • - Article ID 4761427
  • - Review Article

Macrophages Are Key Regulators of Stem Cells during Skeletal Muscle Regeneration and Diseases

Junio Dort | Paul Fabre | ... | Nicolas A. Dumont
  • Special Issue
  • - Volume 2019
  • - Article ID 2785207
  • - Research Article

Identification of Aberrantly Expressed Genes during Aging in Rat Nucleus Pulposus Cells

Shi Cheng | Xiaochuan Li | ... | Yu Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 1839627
  • - Research Article

Mechanical Stretch Promotes the Osteogenic Differentiation of Bone Mesenchymal Stem Cells Induced by Erythropoietin

Yong-Bin He | Sheng-Yao Liu | ... | Guo-Xin Ni
  • Special Issue
  • - Volume 2019
  • - Article ID 1351860
  • - Research Article

Promoting Osteogenic Differentiation of Human Adipose-Derived Stem Cells by Altering the Expression of Exosomal miRNA

Shude Yang | Shu Guo | ... | Xu Sun
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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