Stem Cells International

Basic Biology and Clinical Application of Multipotent Mesenchymal Stromal Cells: From Bench to Bedside


Publishing date
08 Jun 2012
Status
Published
Submission deadline
20 Jan 2012

Lead Editor

1Department of Hematology/Oncology, University Children's Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany

2Institute of Transfusion Medicine and Immune Hematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen, Sandhofstraße 1, 60528 Frankfurt am Main, Germany

3Center for Obstetrics and Paediatrics, Department of Paediatric Hematology and Oncology, Medical Faculty, University of Hamburg, Martinistraße 52, 20246 Hamburg, Germany

4Centro Ricerca “M. Tettamanti,” Clinica Pediatrica, Ospedale San Gerardo, Università Milano-Bicocca, Via Pergolesi 33, 20052 Monza, Italy

5Clinic of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Faculty of Medicine, Heinrich Heine University, Moorenstraße 5, 40225 Düsseldorf, Germany


Basic Biology and Clinical Application of Multipotent Mesenchymal Stromal Cells: From Bench to Bedside

Description

Multipotent mesenchymal stromal cells (MSCs) are nonhematopoietic cells capable of differentiating along at least three lineages: osteoblasts, adipocytes, and chondrocytes. Bone marrow represents the main source of these cells, but they can also be derived from many other different tissues such as adipose tissue, umbilical cord blood, umbilical cord tissue, placenta, skin, dental pulp, and uterus. Their multilineage differentiation potential forms the basis for a multiplicity of applications in regenerative medicine, whereas their broad-spectrum immunomodulatory properties are harnessed in the treatment of inflammatory and (auto)immune diseases. However, in-depth studies of the basic biology of MSC represent a clear prerequisite for their further way into the clinic. In order to highlight the origin of progenitor cells of MSCs, the mechanisms of their immunomodulatory capacity, and their potential to differentiate into many tissue types, the following topics have to be covered in this special issue. Potential topics include, but are not limited to:

  • The origin of MSCs
  • Prospective isolation and expansion of MSCs from bone marrow (plastic adherence versus cell surface markers for their isolation)
  • MSCs isolated from cord blood, cord, and placenta
  • MSCs isolated from adipose and other tissues
  • Ex vivo expansion of MSCs under serum-free conditions
  • Migration and homing of MSCs
  • Immunomodulatory properties of MSCs
  • Clinical use of MSCs for immunosuppression
  • Harnessing the differentiation potential of MSCs in regenerative medicine
  • Cotransplantation of MSCs with hematopoietic stem cells as a strategy to improve their engraftment and multilineage differentiation (experimental and clinical evidence)
  • Safety of the MSC administration
  • Regulatory issues on expansion and release of MSCs preparations for clinical use

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/sci/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 185943
  • - Editorial

Basic Biology and Clinical Application of Multipotent Mesenchymal Stromal Cells: From Bench to Bedside

Selim Kuçi | Reinhard Henschler | ... | Roland Meisel
  • Special Issue
  • - Volume 2012
  • - Article ID 841203
  • - Research Article

Development of a Vascularized Skin Construct Using Adipose-Derived Stem Cells from Debrided Burned Skin

Rodney K. Chan | David O. Zamora | ... | Shanmugasundaram Natesan
  • Special Issue
  • - Volume 2012
  • - Article ID 369417
  • - Research Article

Transplanted Bone Marrow Mesenchymal Stem Cells Improve Memory in Rat Models of Alzheimer's Disease

Parvin Babaei | Bahram Soltani Tehrani | Arsalan Alizadeh
  • Special Issue
  • - Volume 2012
  • - Article ID 342968
  • - Review Article

Journey of Mesenchymal Stem Cells for Homing: Strategies to Enhance Efficacy and Safety of Stem Cell Therapy

Sung Keun Kang | Il Seob Shin | ... | Jeong Chan Ra
  • Special Issue
  • - Volume 2012
  • - Article ID 646038
  • - Review Article

Mesenchymal Stem Cells for Cardiac Regeneration: Translation to Bedside Reality

Mohammad T. Elnakish | Fatemat Hassan | ... | Mahmood Khan
  • Special Issue
  • - Volume 2012
  • - Article ID 414038
  • - Research Article

Directed Fusion of Mesenchymal Stem Cells with Cardiomyocytes via VSV-G Facilitates Stem Cell Programming

Nicholas A. Kouris | Jeremy A. Schaefer | ... | Brenda M. Ogle
  • Special Issue
  • - Volume 2012
  • - Article ID 690236
  • - Clinical Study

Mesenchymal Stromal Cells Do Not Increase the Risk of Viral Reactivation Nor the Severity of Viral Events in Recipients of Allogeneic Stem Cell Transplantation

Giovanna Lucchini | Erica Dander | ... | Giovanna D'Amico
  • Special Issue
  • - Volume 2012
  • - Article ID 946090
  • - Research Article

Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells

Raffaele Nuzzi | Monica Gunetti | ... | Ivana Ferrero
  • Special Issue
  • - Volume 2012
  • - Article ID 309187
  • - Review Article

Engaging Stem Cells for Customized Tendon Regeneration

Hatim Thaker | Arun K. Sharma
  • Special Issue
  • - Volume 2012
  • - Article ID 652034
  • - Review Article

Safety of Mesenchymal Stem Cells for Clinical Application

Youwei Wang | Zhi-bo Han | ... | Zhong Chao Han
Stem Cells International
 Journal metrics
Acceptance rate45%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore3.800
Impact Factor3.902
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