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(Re)generating the Lung: Use of Stem and Progenitor Cells in Lung Regenerative Medicine

Call for Papers

Chronic lung diseases are predicted to continually increase to become the third leading cause of death in the next decade. Limited therapeutic options exist for all of these patients and the only option at end-stage disease is lung transplantation. There is a limited amount of lungs available for transplantation and patients receiving lung transplantation only have 50% survival after 5 years. New approaches are needed.

Regenerative medicine approaches including stem cell therapy and tissue engineering approaches using stem and progenitor cells have received increased attention of late and are a potentially promising potential solution, but there has been limited success translating these ideas into the clinic. Therefore, the aim of this issue is to explore current, emerging and novel strategies in lung regenerative medicine using stem and progenitor cells and to further elucidate their potential in the clinic.

We invite original research articles and review articles that contribute to our understanding of lung stem and progenitor cell biology as well as the potential for stem cell therapy and bioengineering approaches using stem and progenitor cells for patients with chronic lung disease. We encourage submissions that describe new and innovative approaches for ex vivo or endogenous lung regenerative medicine or new models which can be used to evaluate the potential of stem and progenitor cells.

Potential topics include but are not limited to the following:

  • Stem cell therapies and stem cell-derived extracellular vesicles in lung regeneration
  • Stem cell bioengineering approaches for lung tissue engineering
  • Therapeutic applications and biology of endogenous lung stem and progenitor cells
  • Induced pluripotent stem cell derived lung cells and their applications
  • Microenvironment and environment influences on lung stem/progenitor cell behavior
  • Aging/senescence effects on lung stem and progenitor cells Novel stem and progenitor cell delivery strategies for lung regeneration
  • Novel methods and 3D models for assessing lung stem and progenitor cell function
  • Novel biomaterials for use with stem and progenitor cells in lung regeneration
  • Design and validation of novel bioreactors for lung preservation and bioengineering with stem and progenitor cells
  • GMP considerations for lung stem and progenitor cells in regenerative medicine

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 18 May 2018
Publication DateOctober 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

Guest Editors

  • Oskar Hallgren, Lund University, Lund, Sweden
  • Fernanda Cruz, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
  • Amy Firth, University of Southern California, Los Angeles, USA