Stem Cells International

Stem Cell Applications in Regenerative Medicine for Kidney Diseases


Publishing date
01 Jan 2021
Status
Closed
Submission deadline
11 Sep 2020

1Hospital Israelita Albert Einstein, São Paulo, Brazil

2University of Miami Miller School of Medicine, Miami, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Stem Cell Applications in Regenerative Medicine for Kidney Diseases

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Kidney diseases affect millions of people worldwide. Acute kidney injury is associated with a high risk of mortality and increased length of hospitalization, which may ultimately progress to chronic kidney disease (CKD). Diabetes mellitus, systemic hypertension, and glomerulopathies are the main causes of CKD. CKD is incurable and therefore requires dialysis or transplant; however, the shortage of kidney donors limits the availability of transplants. Pursuing progenitor/stem cell-based kidney regenerative strategies, including organoids, scaffolds, and biological devices, is therefore a key step towards the development of bioengineered transplantable organs. Various streams of research have explored the possible application of pluripotent stem cells (SCs; embryonic SCs and induced pluripotent SCs or iPSCs), and adult or fetal tissue-specific stem cells in different strategies aimed at regenerating functioning kidneys.

This special issue invites investigators to contribute original research and review articles discussing the continuing efforts to develop novel progenitor/stem cell-based strategies to repair, replace, or regenerate kidneys following either acute or chronic injury.

Potential topics include but are not limited to the following:

  • Progenitor/stem cell-based therapy and mechanistic insights, such as differentiation, migration, proliferation, engraftment, and paracrine effects using either in vitro or in vivo approaches for acute and chronic kidney diseases
  • Recent advances in cellular and molecular progenitor/stem cell-based therapies to treat kidney diseases
  • Novel developments in kidney tissue bioengineering techniques, which incorporate progenitor/stem cells, biomaterials, decellularized scaffolds, 3D printing tissues, and combined therapies for kidney regeneration
  • Kidney organoids and 3D cultures of progenitor/stem cells as models for developing and engineering tissues and use in disease modelling
  • Kidney-related single-cell and omics analyses for understanding the biological and therapeutic potential of progenitor/stem cells
  • Development of physiologically relevant cellular models using progenitor/stem cells with strong translatability to human kidney pathophysiology
  • Currents concepts in the treatment of kidney disease using nanoparticles, siRNA, genoma editing, viral, and nonviral gene therapy strategies combined to progenitor/stem cell therapy
  • New insights of progenitor/stem cell-based therapy and kidney-related injury using small and large animal models
  • Kidney regeneration and repair using progenitor/stem cell-based strategies in clinical trials

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 8819757
  • - Research Article

Nephroprotective Effect of Mesenchymal Stem Cell-Based Therapy of Kidney Disease Induced by Toxicants

Shujun Lin | Wenshan Lin | ... | Tianbiao Zhou
  • Special Issue
  • - Volume 2020
  • - Article ID 8833725
  • - Review Article

Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells

Christian Sávio-Silva | Stephany Beyerstedt | ... | Érika B. Rangel
  • Special Issue
  • - Volume 2020
  • - Article ID 8814574
  • - Research Article

Comparison of the Effects of Mesenchymal Stem Cells with Their Extracellular Vesicles on the Treatment of Kidney Damage Induced by Chronic Renal Artery Stenosis

Crysthiane Saveriano Rubiao Andre Ishiy | Milene Subtil Ormanji | ... | Mirian Aparecida Boim
  • Special Issue
  • - Volume 2020
  • - Article ID 8894590
  • - Review Article

Differentiating Induced Pluripotent Stem Cells into Renal Cells: A New Approach to Treat Kidney Diseases

Patrícia de Carvalho Ribeiro | Lucas Felipe Oliveira | ... | Heloisa Cristina Caldas
  • Special Issue
  • - Volume 2020
  • - Article ID 1873921
  • - Research Article

The Efficacy of Mesenchymal Stem Cells in Therapy of Acute Kidney Injury Induced by Ischemia-Reperfusion in Animal Models

Tianbiao Zhou | Chunling Liao | ... | Shuangyi Huang
  • Special Issue
  • - Volume 2020
  • - Article ID 3768718
  • - Research Article

Adipose-Derived Mesenchymal Stem Cells Modulate Fibrosis and Inflammation in the Peritoneal Fibrosis Model Developed in Uremic Rats

Elerson C. Costalonga | Camilla Fanelli | ... | Irene L. Noronha
  • Special Issue
  • - Volume 2020
  • - Article ID 6518508
  • - Research Article

Clinical Efficacy and Safety of Mesenchymal Stem Cells for Systemic Lupus Erythematosus

Tianbiao Zhou | Hong-Yan Li | ... | Shujun Lin
Stem Cells International
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Acceptance rate44%
Submission to final decision76 days
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CiteScore7.200
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