Stem Cells International

Mesenchymal Stem Cells: Characteristics, Function, and Application


Publishing date
01 Oct 2018
Status
Published
Submission deadline
18 May 2018

Lead Editor
Guest Editors

1The Third Military Medical University, Chongqing, China

2The Fourth Military Medical University, Xi’an, China

3University of Southern California, Los Angeles, USA


Mesenchymal Stem Cells: Characteristics, Function, and Application

Description

Mesenchymal stem cells (MSCs) are found in vivo at low frequency and are defined by their capacity to differentiate into bone, cartilage, or adipose tissue, and so on. Although MSCs were thought to be the panacea for regenerative medicine, they appear to be also important to regulate the immune response invoked in settings such as trauma, transplantation, and autoimmunity. Recent reports investigated that MSCs have been used in practice to treat graft-versus-host disease, skeleton repair, and tissue regeneration. Successful immune modulation researches suggest efficacy in a wide range of autoimmune conditions, such as multiple sclerosis, systemic lupus erythematosus, and Crohn’s disease.

However, the fundamental machinery of MSCs therapeutic mechanism and different use strategy has yet to be fully elucidated. Thus the potential consequence of MSCs in clinical administration is not fully known yet. Therefore, elucidation of the molecular and cellular mechanisms involved with MSCs function will have broad implications for understanding underlying mechanisms of injury, tissue repair, and regeneration, as well as the immune modulation, and hematopoiesis, which will aid in mammalian health and regenerative medicine.

In this special issue, we invite papers investigating the function of MSCs, including the function of tissue specific MSCs, the differential potential, the immune modulatory feature, the therapeutic outcome in various injuries or diseases, and the valuable administration strategy.

Potential topics include but are not limited to the following:

  • Functional comparison of tissue specific MSCs
  • MSCs differentiation and development mechanism
  • MSCs marker and significant subpopulation characterization
  • MSCs’ contribution to hematopoiesis
  • MSCs’ role in irradiation defense
  • MSCs in immune modulation and implications for diseases
  • MSCs in trauma, injury, and repair machinery
  • The administration strategy (isolation, purification, dosage, and transplantation methods) and efficacy of MSCs

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 5073745
  • - Research Article

Morphological and Molecular Analysis of In Vitro Tubular Structures from Bovine Yolk Sac-Derived MSCs

Celina A. F. Mançanares | Vanessa Cristina de Oliveira | ... | Carlos E. Ambrósio
  • Special Issue
  • - Volume 2019
  • - Article ID 8106818
  • - Editorial

Mesenchymal Stem Cells: Characteristics, Function, and Application

Zhongjun Li | Xingbin Hu | Jiang F. Zhong
  • Special Issue
  • - Volume 2019
  • - Article ID 7274057
  • - Research Article

A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of Primary Cultured Cells and Subcultured Cells Using Mouse Adipose-Derived Mesenchymal Stem Cells

Yoshiki Nakashima | Saifun Nahar | ... | Hirofumi Noguchi
  • Special Issue
  • - Volume 2018
  • - Article ID 9793845
  • - Research Article

Fasudil Promotes BMSC Migration via Activating the MAPK Signaling Pathway and Application in a Model of Spinal Cord Injury

Jiheng Zhan | Jianbo He | ... | Dingkun Lin
  • Special Issue
  • - Volume 2018
  • - Article ID 2891957
  • - Review Article

The Mechanobiology of the Actin Cytoskeleton in Stem Cells during Differentiation and Interaction with Biomaterials

X. Ambriz | P. de Lanerolle | J. R. Ambrosio
  • Special Issue
  • - Volume 2018
  • - Article ID 5450768
  • - Review Article

Detection, Characterization, and Clinical Application of Mesenchymal Stem Cells in Periodontal Ligament Tissue

Atsushi Tomokiyo | Shinichiro Yoshida | ... | Hidefumi Maeda
  • Special Issue
  • - Volume 2018
  • - Article ID 2090276
  • - Research Article

Location, Isolation, and Identification of Mesenchymal Stem Cells from Adult Human Sweat Glands

Yingzhi Ma | Meirong Li | ... | Xiaobing Fu
  • Special Issue
  • - Volume 2018
  • - Article ID 6480793
  • - Research Article

Preconditioning by Hydrogen Peroxide Enhances Multiple Properties of Human Decidua Basalis Mesenchymal Stem/Multipotent Stromal Cells

T. Khatlani | D. Algudiri | ... | M. H. Abumaree
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
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Impact Factor5.443
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