Stem Cells International

Mesenchymal Stem Cell Based Regenerative Treatment of the Knee: From Basic Science to Clinics


Status
Closed

1University Hospital Regensburg, Regensburg, Germany

2Oregon Health & Science University, Portland, USA

3NUI Galway, Galway, Ireland

4Saarland University Medical Center, Saarbrucken, Germany

This issue is now closed for submissions.
More articles will be published in the near future.

Mesenchymal Stem Cell Based Regenerative Treatment of the Knee: From Basic Science to Clinics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Mesenchymal stem cells have been proposed for repair and regeneration of different structures of the knee joint like articular cartilage, meniscus, tendons, and ligaments. Many successful experimental preclinical studies have been published on various topics in this field. However only limited stem cell based approaches for regeneration of knee structures have been introduced into daily clinical practice.

The purpose of this special issue is to publish high quality research articles as well as reviews that address recent developments on the use of mesenchymal stem cells for repair and regeneration of knee structures and the potential of these approaches for clinical translation. It should focus on stem cell based treatment options for the knee that have been successfully introduced into clinical practice or show a high potential for clinical translation. Preclinical findings with a possible high impact on the development of stem cell based repair strategies of knee structures should also be covered in order to improve future developments and identify key hurdles that still remain to be overcome.

Potential topics include but are not limited to the following:

  • Mesenchymal stem cells from different sources for articular-regeneration
  • Translational studies for stem cell based cartilage repair
  • Translational models and improvements in meniscal regeneration by mesenchymal stem cells
  • Endogenous and stem cell induced knee ligament regeneration
  • Knee tendon repair by stem cell based tissue engineering approaches
  • Role and potential of tissue related and locally derived stem cells in the knee
  • Analysis of the role of mesenchymal stem cells during knee structure healing processes and their potential as targets for regenerative treatment strategies
  • Modulation of stem cell based treatment options to improve the outcome and accelerate clinical translation
  • Translational clinical trails for knee structure regeneration
  • Animal models with focus on translational treatment approaches for the knee with mesenchymal stem cells

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 7608718
  • - Editorial

Mesenchymal Stem Cell Based Regenerative Treatment of the Knee: From Basic Science to Clinics

Johannes Zellner | Brian Johnstone | ... | Henning Madry
  • Special Issue
  • - Volume 2019
  • - Article ID 1735242
  • - Review Article

Minimally Manipulated Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence

B. Di Matteo | F. Vandenbulcke | ... | E. Kon
  • Special Issue
  • - Volume 2019
  • - Article ID 9431894
  • - Research Article

Intra-Articular Injection of 2 Different Dosages of Autologous and Allogeneic Bone Marrow- and Umbilical Cord-Derived Mesenchymal Stem Cells Triggers a Variable Inflammatory Response of the Fetlock Joint on 12 Sound Experimental Horses

Lélia Bertoni | Thomas Branly | ... | Magali Demoor
  • Special Issue
  • - Volume 2019
  • - Article ID 9792369
  • - Research Article

A Bioactive Cartilage Graft of IGF1-Transduced Adipose Mesenchymal Stem Cells Embedded in an Alginate/Bovine Cartilage Matrix Tridimensional Scaffold

Nidia K. Moncada-Saucedo | Iván A. Marino-Martínez | ... | Lizeth Fuentes-Mera
  • Special Issue
  • - Volume 2019
  • - Article ID 3826054
  • - Review Article

Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment

Mohamed E. Awad | Khaled A. Hussein | ... | Sadanand Fulzele
  • Special Issue
  • - Volume 2019
  • - Article ID 9310318
  • - Review Article

Head to Knee: Cranial Neural Crest-Derived Cells as Promising Candidates for Human Cartilage Repair

Ihsène Taïhi | Ali Nassif | ... | François Ferré
  • Special Issue
  • - Volume 2019
  • - Article ID 8169172
  • - Research Article

Osteoarthritic Synovial Fluid Modulates Cell Phenotype and Metabolic Behavior In Vitro

Eduardo Branco de Sousa | Gilson Costa dos Santos Junior | ... | Diego Pinheiro Aguiar
Stem Cells International
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