Stem Cells International

Therapeutic Use of Extraembryonic-Derived Tissues


Status
Published

Lead Editor

1Karolinska Institutet, Stockholm, Sweden

2King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

3HBKU, Doha, Qatar


Therapeutic Use of Extraembryonic-Derived Tissues

Description

Umbilical cord blood (UCB), placenta-derived, and other extraembryonic tissue, previously seen as medical waste, is increasingly recognized as a prized source of cells for therapeutic use. The best-known application is in hematopoietic stem cell transplantation (HSCT), where UCB has become an increasingly important graft source in the last 3 decades since umbilical cord blood transplantation (UCBT) was implemented. Recently UCB, placenta, and extraembryonic derived cells and tissues also have been more and more investigated as an acknowledged source regarding adoptive cell therapy.

The nonhematopoietic cell types in UCB, placenta-derived, and extraembryonic cells and tissues include several ones that can be used therapeutically and are readily expanded to sufficient numbers using established methods. The most notable ones of these are mesenchymal stromal cells (MSCs) and endothelial-like vascular progenitors (EPCs). To complicate this further MSCs from different sources of the placenta seem to have very different properties.

Potential topics include but are not limited to the following:

  • Strategies to use lymphocytes from placenta, CB, and extraembryonic tissues for adoptive cell therapy
  • Strategies to use placenta derived MSCs for adoptive cell therapy
  • Different properties of MSCs from various placenta tissues, CB, and extraembryonic tissue
  • Placenta derived tissue and cells in today and future medicine

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 6082698
  • - Editorial

Therapeutic Use of Extraembryonic-Derived Tissues

Michael Uhlin | Mohamed Abumaree | Essam M. Abdelalim
  • Special Issue
  • - Volume 2018
  • - Article ID 8529104
  • - Research Article

Expansion of Gammadelta T Cells from Cord Blood: A Therapeutical Possibility

Sofia Berglund | Ahmed Gaballa | ... | Michael Uhlin
  • Special Issue
  • - Volume 2018
  • - Article ID 7318513
  • - Research Article

Mesenchymal Stromal Cells Support Endometriotic Stromal Cells In Vitro

Fawaz Abomaray | Sebastian Gidlöf | ... | Cecilia Götherström
  • Special Issue
  • - Volume 2018
  • - Article ID 4837930
  • - Review Article

Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects

Olena Pogozhykh | Volodymyr Prokopyuk | ... | Denys Pogozhykh
  • Special Issue
  • - Volume 2017
  • - Article ID 1626741
  • - Research Article

Soft Tissue Repair with Easy-Accessible Autologous Newborn Placenta or Umbilical Cord Blood in Severe Malformations: A Primary Evaluation

Åsa Ekblad | Magdalena Fossum | Cecilia Götherström
  • Special Issue
  • - Volume 2017
  • - Article ID 8010961
  • - Research Article

Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis

Martin Solders | Laia Gorchs | ... | Helen Kaipe
  • Special Issue
  • - Volume 2017
  • - Article ID 5738371
  • - Review Article

Lymphocytes in Placental Tissues: Immune Regulation and Translational Possibilities for Immunotherapy

Tom Erkers | Arwen Stikvoort | Michael Uhlin
  • Special Issue
  • - Volume 2017
  • - Article ID 1732094
  • - Research Article

Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells as a Potential Source for Cartilage and Bone Regeneration: An In Vitro Study

A. Marmotti | S. Mattia | ... | G. M. Peretti
  • Special Issue
  • - Volume 2017
  • - Article ID 5180579
  • - Research Article

Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation

Yun Bin Lee | Jong Ho Choi | ... | Gi Jin Kim
  • Special Issue
  • - Volume 2017
  • - Article ID 3215962
  • - Research Article

Mesenchymal Stromal Cells Are More Immunosuppressive In Vitro If They Are Derived from Endometriotic Lesions than from Eutopic Endometrium

Fawaz Abomaray | Sebastian Gidlöf | Cecilia Götherström
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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