Stem Cells International

Stem Cells in Musculoskeletal Regeneration: From Benchtop to Bedside


Publishing date
29 Apr 2016
Status
Published
Submission deadline
11 Dec 2015

Lead Editor

1University of California, Los Angeles, USA

2Nanyang Technological University, Singapore

3Beihang University, Beijing, China

4The Fourth Military Medical University, Xi'an, China

5Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands


Stem Cells in Musculoskeletal Regeneration: From Benchtop to Bedside

Description

Age-related skeletal diseases such as osteoarthritis and osteoporosis are affecting millions of people in the world. In the last decades, advances in discovering and implementing mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells have spurred stem cell-based therapies in musculoskeletal repair including cartilage, bone, tendon, ligament, meniscus, adipose, and muscle. However, the success of translating stem cells to clinical application needs further understanding of fundamental stem cells biology, development of tissue engineering, and appropriate animal model.

Natural, synthetic, or nanoscale scaffolds that have capability of conductivity or inductivity have been used to deliver stem cells and inductive factors (gene, DNA, and protein) for tissue engineering approach. The deep understanding of interaction of biomaterials and stem cells will promote stem cells-based tissue engineering in musculoskeletal regeneration. In addition, further investigation of how stem cells niche regulates progenitor cells in musculoskeletal tissue maintenance and repair will play an important role in developing novel stem cells approach in clinic.

In this special issue, we cordially invite experts in the fields of stem cells biology, tissue engineering, biomaterials, drug delivery, and orthopaedic surgery to report their latest research and review work on stem cells in musculoskeletal tissue regeneration and fundamental stem cells biology (regulatory mechanisms of self-renewal and differentiation).

Potential topics include, but are not limited to:

  • Interaction of biomaterials and stem cells in musculoskeletal regeneration
  • Stem cells niche (biomechanical, structure, and signaling) affects stem cells in musculoskeletal tissue maintenance and repair
  • Delivery of inductive factors and stem cells using bioscaffold or nanoparticle for musculoskeletal regeneration
  • Novel stem cells-based tissue engineering strategy (autologous or allogeneic stem cells)
  • Stem cells for the treatment of musculoskeletal diseases (osteoarthritis, osteoporosis, and Duchenne muscular dystrophy)
  • Musculoskeletal animal models and clinical trials

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 8432314
  • - Editorial

Stem Cells in Musculoskeletal Regeneration: From Benchtop to Bedside

Jiabing Fan | Dong-An Wang | ... | Fang Yang
  • Special Issue
  • - Volume 2016
  • - Article ID 9842075
  • - Research Article

Effects of Mechanical Stretch on Cell Proliferation and Matrix Formation of Mesenchymal Stem Cell and Anterior Cruciate Ligament Fibroblast

Liguo Sun | Ling Qu | ... | Hongbin Fan
  • Special Issue
  • - Volume 2016
  • - Article ID 6768274
  • - Clinical Study

Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury

Zurab Kakabadze | Nickolas Kipshidze | ... | Konstantine Chutkerashvili
  • Special Issue
  • - Volume 2016
  • - Article ID 7414036
  • - Research Article

Platelet-Rich Plasma Obtained with Different Anticoagulants and Their Effect on Platelet Numbers and Mesenchymal Stromal Cells Behavior In Vitro

Ronaldo José Farias Corrêa do Amaral | Nemias Pereira da Silva | ... | Alex Balduino
  • Special Issue
  • - Volume 2016
  • - Article ID 5385137
  • - Research Article

Fabrication of Core-Shell PEI/pBMP2-PLGA Electrospun Scaffold for Gene Delivery to Periodontal Ligament Stem Cells

Qiao Xie | Lie-ni Jia | ... | Jun Jia
  • Special Issue
  • - Volume 2016
  • - Article ID 4717184
  • - Review Article

Cell-Based Strategies for Meniscus Tissue Engineering

Wei Niu | Weimin Guo | ... | Quanyi Guo
  • Special Issue
  • - Volume 2016
  • - Article ID 6409546
  • - Research Article

A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells

Qing Li | Tong Wang | ... | Zhi-hui Tang
  • Special Issue
  • - Volume 2016
  • - Article ID 2849879
  • - Review Article

Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research

Satoru Morikawa | Takehito Ouchi | ... | Taneaki Nakagawa
  • Special Issue
  • - Volume 2016
  • - Article ID 5328689
  • - Research Article

Lavandula angustifolia Extract Improves the Result of Human Umbilical Mesenchymal Wharton’s Jelly Stem Cell Transplantation after Contusive Spinal Cord Injury in Wistar Rats

Kayvan Yaghoobi | Gholamreza Kaka | ... | Seyed Ruhollah Hosseini
  • Special Issue
  • - Volume 2016
  • - Article ID 9201492
  • - Review Article

Cartilage Defect Treatments: With or without Cells? Mesenchymal Stem Cells or Chondrocytes? Traditional or Matrix-Assisted? A Systematic Review and Meta-Analyses

Zhantao Deng | Jiewen Jin | ... | Haidong Xu
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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