Stem Cells International

Stem Cell Derived Organoids in Human Disease and Development


Publishing date
01 Jun 2019
Status
Published
Submission deadline
08 Feb 2019

1University of Ulm, Ulm, Germany

2Eberhard Karls University Tübingen, Tübingen, Germany

3Duke University School of Medicine, Durham, USA

4University of Colorado Denver, Denver, USA


Stem Cell Derived Organoids in Human Disease and Development

Description

The invention of culture conditions for long-term expansion of even a single LGR5+ intestinal stem cell as crypt-villus structures demonstrated the feasibility to derive complex organ-like structures invitro from primary adult tissues and initiated a wave of studies creating epithelial organoids from every germ layer. Moreover, human pluripotent stem cells (hPSCs) were applied to mimic lineage commitment and later on complemented with organoid-cultures to reach the respective maturation stage. The organ studied best in “organoid cultures” is the gut. Here human intestinal organoids or “mini-guts” are grown in a three-dimensional (3D) culturing system in matrigel and supplied with a specific set of growth factors. In this environment, isolated adult stem cells build crypt-like structures composed of diverse organ-specific cell types recapitulating human tissue architecture and the associated stem cell hierarchy responsible for rapid epithelial turnover and tissue homeostasis in the gut. Meanwhile similar studies were obtained for the pancreas, the lung, and the brain. Therefore these organoids are suitable not only for disease-modelling, drug validation, or engineering personalized therapy strategies, but also for studying tissue development, regeneration, and niche organization across several organs and stem cell niches.

In this special issue, we welcome review and original papers focussing on organoids either derived from adult stem cell compartments or differentiated from pluripotent stem cells. Here, such organoid studies should report on their capacity in disease modelling but also as a superior cell fate determination model. Additionally, we encourage reports on “disease-specific organoid papers,” “new strategies to develop organoid cultures,” “microfluidic or 3D printing approaches,” and their advantage to model disease, test drugs, and assess developmental changes.

Potential topics include but are not limited to the following:

  • Novel culture conditions using organoids
  • Organoids to assess developmental defects
  • Organoids generated from other model organisms
  • Organoids and tissue complexity
  • Polarity and maturation in organoids
  • Inherited and acquired disease in an organoid model
  • Cancer organoids
  • Organoids and individualized medicine
  • 3D printing of tissues and their utilization
  • Microfluidic devices and stem cell derived tissues

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 7919427
  • - Editorial

Stem Cell Derived Organoids in Human Disease and Development

Stefan Liebau | Holger A. Russ | Alexander Kleger
  • Special Issue
  • - Volume 2019
  • - Article ID 4149762
  • - Research Article

The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB

Ziyu Zhu | Leonie Schnell | ... | Holger Barth
  • Special Issue
  • - Volume 2019
  • - Article ID 8472712
  • - Research Article

Development of Collagen-Based 3D Matrix for Gastrointestinal Tract-Derived Organoid Culture

Joo Hyun Jee | Dong Hyeon Lee | ... | Jongman Yoo
  • Special Issue
  • - Volume 2019
  • - Article ID 8475389
  • - Research Article

MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo

Karolin Walter | Kanishka Tiwary | ... | Patrick C. Hermann
  • Special Issue
  • - Volume 2019
  • - Article ID 2079742
  • - Research Article

Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks

Lukas Perkhofer | Melanie Engler | ... | Pierre-Olivier Frappart
  • Special Issue
  • - Volume 2019
  • - Article ID 1378639
  • - Research Article

The Anthrax Toxin Receptor 1 (ANTXR1) Is Enriched in Pancreatic Cancer Stem Cells Derived from Primary Tumor Cultures

Sonia Alcalá | Paola Martinelli | ... | Bruno Sainz
  • Special Issue
  • - Volume 2019
  • - Article ID 1024614
  • - Research Article

CFTR Expression Analysis for Subtyping of Human Pancreatic Cancer Organoids

Alexander Hennig | Laura Wolf | ... | Thilo Welsch
  • Special Issue
  • - Volume 2019
  • - Article ID 3298432
  • - Research Article

Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells

Lisa Nguyen | Lucas-Sebastian Spitzhorn | James Adjaye
  • Special Issue
  • - Volume 2019
  • - Article ID 8010645
  • - Review Article

Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease

L. Schulte | M. Hohwieler | ... | J. Klaus
  • Special Issue
  • - Volume 2019
  • - Article ID 9301382
  • - Review Article

Pancreatic Progenitors and Organoids as a Prerequisite to Model Pancreatic Diseases and Cancer

Meike Hohwieler | Martin Müller | ... | Sandra Heller
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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