Stem Cells International

Identification and Targeting of Stem Cell-Activated Pathways in Cancer Therapy


Status
Published

1Istituto Nazionale Tumori-IRCCS, Naples, Italy

2Baylor College of Medicine, Houston, USA

3Sapienza University of Rome, Rome, Italy


Identification and Targeting of Stem Cell-Activated Pathways in Cancer Therapy

Description

The hierarchical organization and heterogeneity that are present within malignancies have been recently attributed to stem cell-like subset of tumor cells. Cancer Stem Cells (CSCs) have gained an exclusive interest as they are identified to push tumor growth and seed metastasis and are responsible for therapy failure and tumor resistance.

The molecular mechanism that drives the CSCs population has started to emerge and the identification and origin of factors that maintain or even induce a CSC phenotype remain an intense area of research. Beside the countless pathways described in literature, many protocols and techniques are drawn up to isolate and study CSCs.

Purpose of this special issue is to highlight the protocols and techniques to follow CSCs, the CSCs activated-pathways, and related compounds that are described to modulate CSCs activated-pathways, which can subsequently be exploited for therapeutic use.

Potential topics include but are not limited to the following:

  • Technologies to identify and study cancer stem cells in vitro and in vivo
    • 2D and 3D cultures
    • Imaging
    • Cytofluorimetric approach
    • Luc reporter system in vitro ed in vivo
  • Pathways involved in stemness and targetable in cancer therapy
    • Stearoyl-CoA-desaturase modulation
    • Specific stress activated pathways in cancer stem cells and their modulation
    • Microenvironment-related pathways modulated in cancer stem cells
    • Epigenetics modulation of stemness pathways—a stark role of HDAC inhibitors
  • Study cancer stem cell compartment in patients
    • Histopathological markers

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 8549020
  • - Editorial

Identification and Targeting of Stem Cell-Activated Pathways in Cancer Therapy

Alfredo Budillon | Steven Curley | ... | Rita Mancini
  • Special Issue
  • - Volume 2019
  • - Article ID 9280298
  • - Research Article

Human Menstrual Blood-Derived Stem Cells Inhibit the Proliferation of HeLa Cells via TGF-β1-Mediated JNK/P21 Signaling Pathways

Qian-Yu Liu | Feng Ruan | ... | Quan-Wen Liu
  • Special Issue
  • - Volume 2018
  • - Article ID 8908751
  • - Review Article

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

Daniela Trisciuoglio | Marta Di Martile | Donatella Del Bufalo
  • Special Issue
  • - Volume 2018
  • - Article ID 6392198
  • - Review Article

The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles

Chiara Ciardiello | Alessandra Leone | Alfredo Budillon
  • Special Issue
  • - Volume 2018
  • - Article ID 3286949
  • - Research Article

The Myc/Max/Mxd Network Is a Target of Mutated Flt3 Signaling in Hematopoietic Stem Cells in Flt3-ITD-Induced Myeloproliferative Disease

Farhan Basit | Maria Andersson | Anne Hultquist
  • Special Issue
  • - Volume 2018
  • - Article ID 4516454
  • - Review Article

Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells

Petra Gener | Joaquin Seras-Franzoso | ... | Simó Schwartz
  • Special Issue
  • - Volume 2018
  • - Article ID 4837370
  • - Review Article

Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis

Jiasheng Xu | Kaili Liao | Weimin Zhou
  • Special Issue
  • - Volume 2018
  • - Article ID 6013728
  • - Research Article

Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs

Khushboo Agrawal | Viswanath Das | ... | Marián Hajdúch
Stem Cells International
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Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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