Stem Cells International

Heterogeneity of MSC: Origin, Molecular Identities, and Functionality


Publishing date
01 Mar 2019
Status
Published
Submission deadline
02 Nov 2018

Lead Editor
Guest Editors

1Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany

2Western University, London, Canada

3Boston Children's Hospital, Boston, USA


Heterogeneity of MSC: Origin, Molecular Identities, and Functionality

Description

Mesenchymal stromal/stem cells (MSCs) are the subset of stromal cells within nearly all types of tissues over the body with multipotent potential of becoming defined cell types of mesodermal lineages, including osteoblasts, adipocytes, and chondrocytes. Additionally, MSC may contribute to the formation of protective niches by secreting regulatory molecules and cytokines that control the process of immune response after tissue damage. Over the past decades, MSC-based therapy represents an attractive strategy to reconstitute the tissue structure and improve organ function after injury.

Recently, the recognition of the heterogeneity of MSC leads to large body of comparative studies, demonstrating that MSC may function differentially in the context of immune modulation and tissue regeneration upon their origin and surface immunophenotypes. MSCs were in general proposed by the International Society for Cellular Therapy (ISCT) with positive expression of CD73, CD90, and CD105, while lacking the surface maker of CD11b, CD14, CD19, CD34, CD45, CD79a, and HLA-DR. Many studies have now revealed that MSCs are largely tissue-committed progenitors and may display additional tissue-specific expression of surface antigens that categorize MSCs into subpopulations that link not only to the differentiation potential into certain cell lineages but also to their regenerative capacity. The observation is of particular interest in the field of cell-based therapy by utilizing optimal donner cells to maximize the therapeutical benefits. Therefore, the aim of this special issue is to define tissue-specific subsets of MSC that preferentially contribute to regenerating certain types of tissues according to their distinct secreting profile of trophic factors and modulatory property of local immune response.

We invite original research articles as well as review articles that elucidate the heterogeneity of MSC from distinct sources in the context of developmental origin, surface molecular identities, and functionality of regenerating the damaged tissue.

Potential topics include but are not limited to the following:

  • Novel surface markers that define subset of MSC
  • Paracrine profile of tissue-specific MSC (exosome, cytokine, and tropic factors)
  • Comparative study using tissue-specific MSC
  • Cultivation-associated changes of surface markers
  • New cell lineages/subpopulations of MSCs with regenerative potential
  • Developmental origin of tissue-specific MSC
  • Functional comparison of different sources of MSC
  • Aging-associated difference of MSC
  • Lineage commitment MSC and progenitors

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 9281520
  • - Editorial

Heterogeneity of MSC: Origin, Molecular Identities, and Functionality

Xueqing Liu | Tao Rui | ... | Zhaoping Ding
  • Special Issue
  • - Volume 2019
  • - Article ID 1613701
  • - Research Article

The Influence of Cell Source and Donor Age on the Tenogenic Potential and Chemokine Secretion of Human Mesenchymal Stromal Cells

Weronika Zarychta-Wiśniewska | Anna Burdzińska | ... | Leszek Pączek
  • Special Issue
  • - Volume 2019
  • - Article ID 8717694
  • - Research Article

CD73 Expression on Mesenchymal Stem Cells Dictates the Reparative Properties via Its Anti-Inflammatory Activity

Kezhe Tan | Hongtao Zhu | ... | Xiaoming Deng
  • Special Issue
  • - Volume 2019
  • - Article ID 9178436
  • - Research Article

Does the Harvesting Site Influence the Osteogenic Potential of Mesenchymal Stem Cells?

Van Thi Nguyen | Irene Tessaro | ... | Laura Mangiavini
  • Special Issue
  • - Volume 2019
  • - Article ID 2175273
  • - Research Article

Isolation and Characterization of an Adult Stem Cell Population from Human Epidural Fat

Nedaa Al-Jezani | Roger Cho | ... | Frank G. Lyons
  • Special Issue
  • - Volume 2019
  • - Article ID 8387350
  • - Review Article

Mesenchymal Stem Cells in Renal Fibrosis: The Flame of Cytotherapy

Quan Zhuang | Ruoyu Ma | ... | Yingzi Ming
  • Special Issue
  • - Volume 2019
  • - Article ID 5690345
  • - Research Article

Skeletal Muscle Resident Progenitor Cells Coexpress Mesenchymal and Myogenic Markers and Are Not Affected by Chronic Heart Failure-Induced Dysregulations

R. I. Dmitrieva | T. A. Lelyavina | ... | A. A. Kostareva
  • Special Issue
  • - Volume 2018
  • - Article ID 5965727
  • - Research Article

Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs)

Ruiping Chen | Wenxiu Xie | ... | Ping Zhu
  • Special Issue
  • - Volume 2018
  • - Article ID 8693137
  • - Review Article

Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity

Kenji Tsuji | Shinji Kitamura | Jun Wada
  • Special Issue
  • - Volume 2018
  • - Article ID 2472137
  • - Review Article

Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations

Elize Wolmarans | Sulette Nel | ... | Michael S. Pepper
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