Stem Cells International

Mesenchymal Transitions in Development and Disease


Publishing date
22 Apr 2016
Status
Published
Submission deadline
04 Dec 2015

Lead Editor

1University of Milano-Bicocca, Monza, Italy

2Brown University, Providence, USA

3University Pompeu Fabra, Barcelona, Spain

4National Taiwan University, Taipei, Taiwan


Mesenchymal Transitions in Development and Disease

Description

Mesenchymal transition (MT) is required for the formation of several tissue and organs during development. Indeed, cells change their specific phenotype to a mesenchymal-like one, involving a complex cell and genetic program that leads to the loss of cell-cell interactions and cell polarity with concomitant acquisition of mesenchymal markers and a distinct migratory behavior. Evidence progressively accumulates that MT is not confined to the embryonic development but is an important mechanism reactivated at the onset of several pathologies. MT is at the basis of the metastatic dissemination of solid tumor cells, a complex process that requires active migration and intra/extravasation. Importantly MT is the general mechanism that triggers and worsens diseases with a fibrotic component being primary cause of morbidity and a major cause of comorbidity of a broad spectrum of diseases including severe blood and vascular disorders and several complex diseases such as diabetes, for which there is a critical need to develop new and more optimized therapeutic approaches.

The network of cellular interactions and signaling pathways underlying MT in physiological and pathological conditions is extremely complex. A crescent number of studies are providing more and more information on the signaling pathways leading to this change of cell identity and ultimately to the onset/exacerbation of the pathological features of these diseases. However how the overall process is regulated is still far from being fully elucidated and many open questions need to be answered to better understand the underlying mechanisms and develop new and specific diagnostic and therapeutic tools.

The main focus of this special issue will be to put together studies that use different experimental approaches and in vivo or in vitro models to in-depth dissection of the dynamic changes of identity of different progenitors, their crosstalk with the tissue microenvironment, and their contribution to normal tissue remodeling versus onset of pathological condition.

Manuscripts reporting translation of basic cell and developmental biology to therapeutic approaches will be welcome, as well as reviews summarizing the most recent developments and ideas in the field.

Potential topics include, but are not limited to:

  • MT and embryonic development
  • Signaling pathways in MT
  • Physiological and pathological MT in selected adult tissues: skin, lung, kidney, muscle, vasculature, central nervous system, and so on
  • MT and tumor progression
  • The immune system and MT
  • Emerging therapeutic options

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5107517
  • - Editorial

Mesenchymal Transitions in Development and Disease

Damian Medici | Pura Muñoz-Cánoves | ... | Silvia Brunelli
  • Special Issue
  • - Volume 2016
  • - Article ID 8419104
  • - Review Article

Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling

Luca Genovese | Andrea Brendolan
  • Special Issue
  • - Volume 2016
  • - Article ID 6962801
  • - Review Article

Endothelial-Mesenchymal Transition in Regenerative Medicine

Damian Medici
  • Special Issue
  • - Volume 2016
  • - Article ID 4636859
  • - Review Article

Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis

Pier Andrea Nicolosi | Enrico Tombetti | ... | Angelo A. Manfredi
  • Special Issue
  • - Volume 2016
  • - Article ID 2732705
  • - Review Article

Noncoding RNAs in Tumor Epithelial-to-Mesenchymal Transition

Ching-Wen Lin | Pei-Ying Lin | Pan-Chyr Yang
  • Special Issue
  • - Volume 2016
  • - Article ID 3543678
  • - Review Article

Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis

Raffaele Strippoli | Roberto Moreno-Vicente | ... | Marco Tripodi
  • Special Issue
  • - Volume 2016
  • - Article ID 9762959
  • - Review Article

Endothelial Plasticity: Shifting Phenotypes through Force Feedback

Guido Krenning | Valerio G. Barauna | ... | Jan-Renier A. J. Moonen
  • Special Issue
  • - Volume 2016
  • - Article ID 2953727
  • - Review Article

Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the “Reactive” Biliary Epithelial Phenotype

Luca Fabris | Simone Brivio | ... | Mario Strazzabosco
  • Special Issue
  • - Volume 2016
  • - Article ID 6213872
  • - Review Article

Vitamin D and the Epithelial to Mesenchymal Transition

María Jesús Larriba | Antonio García de Herreros | Alberto Muñoz
  • Special Issue
  • - Volume 2016
  • - Article ID 6439864
  • - Review Article

Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis

Hsiao-Fan Chen | Kou-Juey Wu
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor3.869
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