Stem Cells International

The Use of Stem Cells in Orthopaedics from Bench to Bedside


Publishing date
01 Aug 2021
Status
Closed
Submission deadline
19 Mar 2021

1Humanitas Clinical and Research Institute, Milan, Italy

2IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

3University Hospital Basel, Basel, Switzerland

This issue is now closed for submissions.
More articles will be published in the near future.

The Use of Stem Cells in Orthopaedics from Bench to Bedside

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The use of mesenchymal stem cells (MSCs) in orthopaedics has encountered a large rise in the last decade, to treat disparate degenerative diseases, such as tendinopathies, muscle injuries and osteoarthritis. Despite some clinical trials having already been published, the application of MSCs is subject to a number of variables that should be carefully considered: the different harvest sites and the inherent biologic differences existing, the manipulation process to obtain MSCs (minimal or extensive), and the application modalities and therapeutic protocols.

There are relevant procedural, regulatory and ethical aspects concerning the application of MSCs. Firstly, there is ongoing in vitro and animal research to understand the mechanisms of action of MSCs in different musculoskeletal tissues, which is fundamental to provide patients with reliable information on what to expect from MSCs application for a specific pathology. Furthermore, many harvest sites and harvest techniques have been described, employing different devices and different preparation methods, ranging from minimal manipulation (i.e. centrifugation or mechanical separation) to cell expansion in the lab. Lastly, different therapeutic protocols have been tested and strategies to enhance the outcomes of MSCs have been attempted, such as biologic adjuvants, biomaterials, and scaffolds.

Amid this rapidly evolving scenario, there is the need of summarising the available evidence. Therefore, the aim of this Special Issue is to collate both original and review articles that shed light on the role of MSCs in the treatment of musculoskeletal conditions and on how to safely and effectively adopt this novel biologic strategy. We aim to solicit submissions from both clinicians without experience in the field able to collect all the essential data to properly inform patients and decide on a preferred approach, as well as from experienced clinician who can report the most updated news on the topic and future trends of research. Furthermore, we also welcome submissions that address regulatory and ethical concerns, including understanding rules and limitations existing among different countries as this is mandatory to guarantee the safety of the patient and to ensure adherence to the best standard of care and research.

Potential topics include but are not limited to the following:

  • In vitro and animal studies on MSCs in orthopaedics
  • Source of MSCs for orthopaedic application
  • Biologic actions of MSCs in osteoarthritis
  • Biologic actions of MSCs towards tendon and muscle tissues
  • MSCs harvest strategies
  • MSCs manipulation process (minimal vs extensive and novel approaches)
  • Application modalities
  • Strategies to increase the efficacy of MSCs (adjuvants, scaffold, biomaterials)
  • Clinical studies dealing with results of application of MSCs
  • Insights on regulatory and ethical aspects regarding the use of MSCs
  • Future trends in the field of MSCs in orthopaedics

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 9964877
  • - Research Article

Mesenchymal Stem Cell Sheet Promotes Functional Recovery and Palliates Neuropathic Pain in a Subacute Spinal Cord Injury Model

Kazuyoshi Yamazaki | Masahito Kawabori | ... | Miki Fujimura
  • Special Issue
  • - Volume 2021
  • - Article ID 9921015
  • - Research Article

Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Years

Nima Heidari | Tiffanie-Marie Borg | ... | Ali Noorani
  • Special Issue
  • - Volume 2021
  • - Article ID 5558040
  • - Review Article

Cell-Based Therapies for the Treatment of Shoulder and Elbow Tendinopathies: A Scoping Review

Berardo Di Matteo | Riccardo Ranieri | ... | Alessandro Castagna
  • Special Issue
  • - Volume 2021
  • - Article ID 6648437
  • - Research Article

Gender-Specific Response in Pain and Function to Biologic Treatment of Knee Osteoarthritis: A Gender-Bias-Mitigated, Observational, Intention-to-Treat Study at Two Years

Tiffanie-Marie Borg | Nima Heidari | ... | Adrian Wilson
  • Special Issue
  • - Volume 2021
  • - Article ID 6632052
  • - Review Article

Stromal Vascular Fraction and Amniotic Epithelial Cells: Preclinical and Clinical Relevance in Musculoskeletal Regenerative Medicine

Francesca Veronesi | Melania Maglio | ... | Milena Fini
Stem Cells International
 Journal metrics
Acceptance rate44%
Submission to final decision76 days
Acceptance to publication35 days
CiteScore7.200
Impact Factor5.443
 Submit

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.