Stem Cells International

Reevolution of Tissue Regeneration: From Recent Advances in Adipose Stem Cells to Novel Therapeutic Approaches


Publishing date
01 Mar 2020
Status
Published
Submission deadline
25 Oct 2019

1Azienda Ospedaliera Universitaria Ospedali Riuniti, Ancona, Italy

2State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania

3AOU Ospedali Riuniti di Ancona, Ancona, Italy

4University of Verona, Verona, Italy

5University of Debrecen, Debrecen, Hungary


Reevolution of Tissue Regeneration: From Recent Advances in Adipose Stem Cells to Novel Therapeutic Approaches

Description

Basic and translational research and clinical trials in stem cell biology are aimed at investigating the ability of adipose stem cells (ASCs) to enhance tissue and organ regeneration and suggest that ASCs in 3D scaffolds may be a potential alternative for wound healing, orthopedic tissue repair and tissue reconstruction after surgery. The development of regenerative medicine strategies requires an appropriate phenotypically stable and well-characterized cell source and a scaffold or “smart” biomaterials (novel “intelligent” biomaterials with appropriate physical properties that is able to support in vivo the commitment of adipose stem cells), together with a suitable microenvironment to provide the necessary cues and signals for cell growth and tissue formation. The proliferation and differentiation of ASCs can be regulated biochemically, as well as through modulation of the physical properties of the microenvironment, such as scaffold topography, the “stiffness,” and mechanical forces. However, there are many unanswered questions concerning the basic cellular biology of ASCs in situ, their differentiation potential in vitro and in vivo, and the mechanisms involved in regeneration.

ASCs have traditionally been cultured in conventional 2D conditions; however 3D tissue engineering scaffolds are better able to mimic the in vivo cellular microenvironment and more effectively recapitulate the physiological setting, resulting in improved localization, attachment, proliferation, and differentiation of ASCs. Significantly, it has been demonstrated that ASCs are able to attach, grow, and proliferate well on biocompatible scaffolds. Tissue reconstruction represents one of the most significant challenges in all surgical procedures. Scaffold design necessitates optimization of polymer blends, interpenetrating matrices, and composites used for the production of matrices in order to achieve the proper mechanical and biological characteristics required for regenerative medicine. Recently, the importance of nanostructured matrices that mimic the nanofibrous structure of the natural ECM has been recognized, together with the role that matrix topology plays in determining cellular structure, function, and differentiation. Consequently, scaffold-cell interactions are vital for the successful application of ASCs in transplantation and tissue reconstruction.

This special issue invites investigators to submit original research and review articles addressing the cell biology of ASCs, their potential for tissue engineering, biomaterial properties, and new information about methods for their characterization. Submissions are welcomed with a particular focus on the interplay between cells and biomaterials, establishing a guide for improving current strategies to refine tissue constructs for effective tissue repair in regenerative medicine.

Potential topics include but are not limited to the following:

  • Isolation and characterization of ASC subpopulations
  • The in vitro and in vivo perivascular ASCs niche
  • Interactions between mesenchymal stem cells and biomaterials for regenerative medicine applications
  • Applications for ASC-based strategies in pathological conditions
  • In vivo models: enhancement of organ and tissue regeneration after ASC transplantation
  • Regenerative medicine and novel therapeutic technologies

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 2179429
  • - Editorial

Reevolution of Tissue Regeneration: From Recent Advances in Adipose Stem Cells to Novel Therapeutic Approaches

Francesco De Francesco | Csaba Matta | ... | Ali Mobasheri
  • Special Issue
  • - Volume 2020
  • - Article ID 4242130
  • - Research Article

Human Adipose Derived Cells in Two- and Three-Dimensional Cultures: Functional Validation of an In Vitro Fat Construct

Robert Bender | Michelle McCarthy | ... | Trivia Frazier
  • Special Issue
  • - Volume 2020
  • - Article ID 9123281
  • - Research Article

Copper Does Not Induce Tenogenic Differentiation but Promotes Migration and Increases Lysyl Oxidase Activity in Adipose-Derived Mesenchymal Stromal Cells

Marta Milewska | Anna Burdzińska | ... | Leszek Pączek
  • Special Issue
  • - Volume 2020
  • - Article ID 1823427
  • - Research Article

Safety and Localization of Mesenchymal Stromal Cells Derived from Human Adipose Tissue-Associated Hyaluronic Acid: A Preclinical Study

Janaína José dos Santos Machado | Bernard Gomes Piñeiro | ... | Regina Coeli Goldenberg
  • Special Issue
  • - Volume 2020
  • - Article ID 9567362
  • - Research Article

The Fabrication and Evaluation of a Potential Biomaterial Produced with Stem Cell Sheet Technology for Future Regenerative Medicine

Shukui Zhou | Ying Wang | ... | Qiang Fu
  • Special Issue
  • - Volume 2020
  • - Article ID 8595940
  • - Research Article

Comparative Analysis of Adipose-Derived Stromal Cells and Their Secretome for Auricular Cartilage Regeneration

Se-Joon Oh | Kyung-Un Choi | ... | Kyu-Sup Cho
  • Special Issue
  • - Volume 2020
  • - Article ID 7056261
  • - Review Article

The Role of Adipose-Derived Stem Cells, Dermal Regenerative Templates, and Platelet-Rich Plasma in Tissue Engineering-Based Treatments of Chronic Skin Wounds

Massimo Conese | Luigi Annacontini | ... | Aurelio Portincasa
  • Special Issue
  • - Volume 2020
  • - Article ID 9625798
  • - Research Article

Transplantation Site Affects the Outcomes of Adipose-Derived Stem Cell-Based Therapy for Retinal Degeneration

Chengyu Hu | Huanzhi La | ... | Haibin Tian
  • Special Issue
  • - Volume 2019
  • - Article ID 1358267
  • - Research Article

The Effect of Blood-Derived Products on the Chondrogenic and Osteogenic Differentiation Potential of Adipose-Derived Mesenchymal Stem Cells Originated from Three Different Locations

Markus Neubauer | Olga Kuten | ... | Stefan Nehrer
  • Special Issue
  • - Volume 2019
  • - Article ID 9276398
  • - Research Article

Human Adipose-Derived Hydrogel Characterization Based on In Vitro ASC Biocompatibility and Differentiation

Omair A. Mohiuddin | Benjamen T. O’Donnell | ... | Jeffrey M. Gimble
Stem Cells International
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.