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Volume 2012 (2012), Article ID 129516, 12 pages
Review Article

Adjudication of the Alleged Role of Vitamin D in the Antimicrobial Pathway

1Schools of Pharmacy and Medicine and the Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
2School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA

Received 22 May 2012; Accepted 13 June 2012

Academic Editors: P. Bouvet, J. A. Castro, and Y. Chagnon

Copyright © 2012 Gerald M. Higa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Dynamic interactions between microorganism and host have evolved in such a way that while microbial pathogens are the cause of many human infections, a symbiotic relationship is also known to exist. Another important anomaly is that exposure to pathogenic organisms does not necessarily result in development of clinical disease. The latter conclusion infers that susceptibility to infectious disease can be modified by host-related factors. Arguably the two most prominent factors are genetic variability and immunologic status of the exposed individual. Because of the Human Genome and the HapMap projects, developments in genotyping technology have brought the possibility of identifying associations between specific genetic alterations and common diseases closer to reality. In addition, a growing body of evidence suggests vitamin D has an important contributory role in the antimicrobial pathway.