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Scientifica
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2012
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Article
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Tab 3
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Review Article
The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance
Table 3
Clinically relevant INI compound structures.
Drug candidate
Chemical structure
Activity Targeted
Phase of development
RAL
Strand Transfer
Approved by FDA in 2007
EVG
Strand Transfer
Approved by FDA in 2012
DTG
Strand Transfer
Phase III
MK-2048
Strand Transfer
Phase 2b/ PREP microbicide
S/GSK-1265744
Strand Transfer
Phase IIa
BI 224436
3
ā
Processing
Phase Ia