The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance

Table 3

Clinically relevant INI compound structures.

Drug candidate	Chemical structure	Activity Targeted	Phase of development
RAL		Strand Transfer	Approved by FDA in 2007
EVG		Strand Transfer	Approved by FDA in 2012
DTG		Strand Transfer	Phase III
MK-2048		Strand Transfer	Phase 2b/ PREP microbicide
S/GSK-1265744		Strand Transfer	Phase IIa
BI 224436		3^’ Processing	Phase Ia