The Genetics of Alzheimer’s Disease

Table 1

Genes responsible for early onset Alzheimer’s disease, including chromosomal location and function.

Gene name (symbol)	Chromosomal location	Function of encoded protein
Amyloid precursor protein (APP)	21q21.3	Implicated in neuronal development and synaptic formation and repair
Presenilin one (PSEN1)	14q24.2	Cleavage of the amyloid precursor protein and NOTCH receptor proteins via overlapping, but distinct mechanisms [12, 13]
Presenilin two (PSEN2)	1q42.13