Table 1: Genes responsible for early onset Alzheimer’s disease, including chromosomal location and function.

Gene name (symbol)Chromosomal locationFunction of encoded protein

Amyloid precursor protein (APP)21q21.3Implicated in neuronal development and synaptic formation and repair
Presenilin one (PSEN1)14q24.2Cleavage of the amyloid precursor protein and NOTCH receptor proteins via overlapping, but distinct mechanisms [12, 13]
Presenilin two (PSEN2)1q42.13