TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets

Figure 1

Over-expression of TRPM7 channel in human pancreatic adenocarcinoma. Anti-TRPM7 immunoreactivity in pancreatic tissues was analyzed using TRPM7-specific antibodies, and the reaction was detected by using 3,3′-diaminobenzidine followed by counterstaining with hematoxylin. The brown color indicates expression of TRPM7 protein in pancreatic adenocarcinoma. Control for immunohistochemistry includes consecutive histological sections from the same paraffinized block being processed in parallel without anti-TRPM7 antibodies. Relative low level of anti-TRPM7 immunoreactivity was detected in the controls (data not shown).