TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets

Figure 3

Aberrant expression of TRPM8 channels in human pancreatic adenocarcinoma. Anti-TRPM8 antibodies were employed for immunohistochemical analysis of pancreatic tissues, followed by color reactions using 3,3′-diaminobenzidine and counterstaining with hematoxylin. Expression of TRPM8 protein in pancreatic adenocarcinoma is indicated by the brown color. Consecutive histological sections from the same paraffinized block were processed in parallel in the absence of anti-TRPM8 antibodies as control, and there is no specific anti-TRPM8 immunoreactivity being detected (data not shown).