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Volume 2012, Article ID 513192, 14 pages
Review Article

Regulatory Mechanisms of Injury and Repair after Hepatic Ischemia/Reperfusion

Department of Surgery, College of Medicine, University of Cincinnati, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45267-0558, USA

Received 1 August 2012; Accepted 12 September 2012

Academic Editors: F. Afaq, S. Nitecki, C. Peralta, and A. G. Zapata

Copyright © 2012 Alex B. Lentsch. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatic ischemia/reperfusion injury is an important complication of liver surgery and transplantation. The mechanisms of this injury as well as the subsequent reparative and regenerative processes have been the subject of thorough study. In this paper, we discuss the complex and coordinated responses leading to parenchymal damage after liver ischemia/reperfusion as well as the manner in which the liver clears damaged cells and regenerates functional mass.