The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response

Figure 2

Domain structure of human KEAP1. NTR: N-terminal region (amino acids 1−60); BTB: broad complex, Tramtrack, Bric-á-brac (amino acids 61–179). KEAP1 forms a homodimer through the BTB binding domain; IVR: intervening region (amino acids 180–314); Kelch domain (amino acids 315–598). The Kelch domain is the binding site with NRF2; CTR: C-terminal region (amino acids 599–624). The positions of the cysteine residues are indicated with yellow bars. The most commonly modified cysteine residues by sulfhydryl-reactive small molecules are shown in red.