Scientifica / 2012 / Article / Tab 1

Review Article

The Insulin-Like Growth Factor System and Nutritional Assessment

Table 1

The insulin-like growth factor binding proteins (IGFBPs).

IGFBP (kDa)Relative affinity for IGFsPossible functions

125Inhibition of growth-promoting actions of IGFs and inhibition of insulin-like actions, integrin binding, glucose homeostasis
231Stimulation of splenic growth, suppression of IGF bioactivity, cell surface binding, mitogenic for some cell types
329Inhibition of IGF actions, induction of apoptosis
426Inhibition or enhancement of IGF actions, inhibition of ovarian steroidogenesis, regulation of bone formation
528Localises IGFs in extracellular matrix and bone, regulation of IGF bioavailability
623Inhibition of actions of IGF-II

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