The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target
Figure 3
The amyloid hypothesis of Alzheimer’s disease and the role of tau. Evidence supports the formation and aggregation of the amyloid β-protein as the initiator of the disease process, with tau playing a subsequent role. Possible Aβ-induced pathological changes in tau include hyperphosphorylation or aggregation.
