Molecular Cochaperones: Tumor Growth and Cancer Treatment

Table 1

Cochaperones.

Name	Function	Conserved domain	Role in cancer	Associated proteins	Reference
Hsp70
JDP	Substrate selection	J	Supp	—	[101–105]
HspBP1	Nucleotide exchange	—	Supp	—	[96–99]
Bag1	Nucleotide exchange	BAG, UBL	Onc		[92]
Bag3	Nucleotide exchange	BAG, WW	Onc	HspB8	[90, 91, 93]
Hop	Adaptor	TPR	Onc	TDB proteins	[107–109]
Hsp90
Sgt1	Substrate selection	CHORD	—	Hsp70	[116–119]
P23	ATPase inhibitor	p23	Onc	—	[112–115]
Aha1	ATPase inhibitor	Aha1	Onc	—	[131, 132]
Cdc37	ATPase inhibitor	Hsp90 bd	Onc	Kinases	[120–129]
Hop	Adaptor	TPR	Onc	TDB	[107–109]
Cyp40	Immunophilin	TPR, PPiase	—	TDB	[32, 134]
FKBP1	Immunophilin	TPR, PPiase	Onc	TDB	[135, 136]
FKBP2	Immunophilin	TPR, PPiase	Onc	TDB, dynein	[134, 137, 138]
PP5	Protein phosphatase	TPR	—	TDB	[139–147]
TTC4	Adaptor, replication	TPR	Supp	TDB, Myst, MOF	[148–153]
TTC5	Adaptor, transcription	TPR	—	TDB, p300	[88, 154–157]
XAP2	Nuclear receptors	TPR	—	TDB	[158–161]