Approaches to the prevention and diagnosis of IA.
|Strategy||Rationale||Laboratory diagnostic use|
|Prophylaxis||Prevention of infection using antifungal treatment and protective accommodation||None|
|Empiric||Early antifungal therapy in response to non-specific signs and symptoms||None (blood cultures are typically done to detect bacteremia and fungemia)|
|Preemptive||Antifungal therapy in response to early specific markers of IA||CT, GM, PCR, and BDG usually one or two markers triggering therapy|
|Targetted||Antifungal therapy of clearly defined cases of IA||All available investigations, using EORTC-MSG criteria|